Pathology of peritoneal mesothelioma

By | April 23, 2012

Pathology of peritoneal mesothelioma, peritoneal mesothelioma can be divided according to pathological adenomatoid mesothelioma, cystic mesothelioma and malignant mesothelioma in three categories, the first two are benign tumors.
1. Adenomatoid mesothelioma (adenomatoid mesothelioma) of this type is less common, but in the tubal corner, uterine body, or attached to the bottom of innocent, etc., often solitary, is l the main tumor. Hard tumor, cut surface solid, grayish yellow or gray pink. There is a limit of light microscopy, but no capsule, the fibrous stroma and composed of many tubular compartment. Ultrastructure between the mesothelial origin.
2. Cystic mesothelioma (cystic mesothelioma) ranging from the size of the tumor from a few, it meters to tens of centimeters in the composition of thin-walled cysts, occur in the visceral peritoneum, easy and adjacent organs with the first 11, may have pseudo-capsule. Light microscope, the tumor wall and the loose connective tissue by the micro-structure, than the walls lined with single layer cuboidal and squamous epithelium. Slightly inconsistent with the tumor cells, abundant cytoplasm, nuclei stained. With colloidal iron staining of tumor (CD-positive, after digestion with hyaluronidase by Colloidal iron staining (HC)) negative, indicating that the positive material is hyaluronic acid.
3. Malignant mesothelioma tumors usually involved the parietal and visceral peritoneum, peritoneal creeping extension of Austin with the growth of peritoneal dirty, widely distributed parietal gray tumor nodules of varying sizes, some synthesis of large tumor masses, part of the tumor serosa appear before the large armor-like thickening, extensive intra-abdominal adhesions, intestinal form of pellets, omentum was "pie", severe chest and pelvic fengchuan cross. Small number of cases the tumor nodules of varying sizes for the grape-like vesicles. Little direct invasion of the tumor within the organ, 50% to 70% of the patients lymph nodes and hematogenous metastasis, lymph node metastasis Yi common to the liver. Light microscope, malignant mesothelioma can be divided into three types:
epithelial type: is the most common histological to tubular papillary structure is most common.
fiber types: primary tumor cells classified as spindle cell component, which is divided into desmoid tumor of the sarcomatoid mesothelioma and mesothelial, l: Vl.
Pathology of peritoneal mesothelioma, mixed: there is epithelial tissue and mesothelioma sarcomatoid component, and sometimes seen under the same field or two components of the coexistence of two components of the transitional forms.

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