Pathology of malignant lymphoma, HL, and EB virus infection significantly correlated; have HIV infection in people, their incidence of HL is slightly higher than some of the general population, and HIV-related clinical manifestations of HL is a complex disease, often in late, involving a number of rare parts, such as bone marrow, skin and meninges and so on.
Viral infections and abnormal immune regulation associated with the occurrence of NHL, and the interaction between these two mechanisms. 1A the virus from the human T cell leukemia virus type 1 (at TLV-1) and adult T cell leukemia associated; human immunodeficiency virus (HIV) causes AIDS incidence, which caused defects in immune function and high grade B cells in the pathogenesis of lymphoma; hepatitis C virus (HeV) infection and the inert B-cell lymphoma pathogenesis.
EB virus DNA virus (EBV) gene has been found in African Burkitt lymphoma cell genome; Helicobacter pylori (Helicobacter pylori, HP), chronic infection and gastric lymphoma significantly between the treatment of clear HP can make 1 / 3 of gastric lymphoma have been alleviated. Lowered immune deficiency and immune status associated with the occurrence of NHL, including AIDS, organ transplant recipients, chronic immune deficiency syndrome (Yuan agammaglobulinemia, Bo, a plug syndrome, an Austrian Wei syndrome), autoimmune diseases (Sjogren's syndrome, rheumatic disease, lupus erythematosus, Hashimoto's thyroiditis) and so on. Phenytoin and other drugs and radiation can cause lymphoproliferative diseases from any stage to the lymphoma disease.
Lymphoma pathology, histopathological diagnosis of lymphoma is mainly based, complete lymph node biopsy for diagnosis of lymphoma is very important. Generally judged to be malignant lymphoma based on the histological structure of the major damage to the normal lymph nodes, capsular invasion and lymph node cells showed heteromorphism.