Irinotecan adverse reactions (1) acute cholinergic syndrome. Manifested as sweating, tears, salivation, reduced bore, blurred vision, abdominal pain twin recover from illness. Mild may relieve itself seriously, need to atropine treatment (0.25mg, subcutaneously). Of severe cholinergic syndrome, the first 2 should be prophylactic atropine administration.
(2), gastrointestinal reactions. Nausea, vomiting, common, should prophylactic use of antiemetic drugs. Delayed diarrhea more common for the dose-limiting toxicity, the rate was 80% -90% 3-4 accounted for 39%. More than 24h after the diarrhea, the median time was 5 days after treatment, the average for 4 days. Diarrhea when given to Los warm D plastic (easy to Mongolia stop) treatment is effective, usage is: the first dose of 4mg oral, then every 2h oral 2mg, the last water sample and after 12h stop, continuous administration no more than 48 severe diarrhea required intravenous rehydration .
Irinotecan adverse reactions (3) bone marrow suppression. Primarily neutropenia, which accounted for 39.6% of 3-4 degrees for the dose-limiting toxicity.
(4) liver damage. Of bilirubin more than 1.5 times the upper limit of normal should ban the FDA.
Irinotecan adverse reactions (5) other. Alopecia, oral mucositis, fatigue, skin toxicity (including a full syndrome) and so on.