Common tumor markers in lung cancer

By | December 26, 2011

Common tumor markers in lung cancer tumor tissue and cell refers as oncogenes, tumor suppressor genes, other tumor genes and tumor-related genes and their products produced by abnormal expression of biologically active substances. Some of a tumor-specific, such as prostate cancer specific antigen (PSA), also for a total of several tumors, such as carcinoembryonic antigen (CEA) and so on.
Lung tumor markers commonly used are:
(1), carcinoembryonic antigen CEA: an epitope of human embryos acid glycoprotein. 2 / 3 of non-small cell lung cancer and 1 / 3 of patients with small cell lung cancer CEA levels.
(2) CYFRA21. 1 (cytokeratin fragment antigen 21.1): It is a very active current research, a new marker for lung cancer, non-small cell lung cancer CYFRA21.1 sensitivity of 52% — 60%, in particular, is the sensitivity of squamous cell carcinoma more than 75%.
(3) nerve-specific enolase (NSE): in the past that the NSE is a small cell lung cancer specific antigen, but now found that about 10% — 30% of non-small cell lung cancer with elevated NSE.
(4) Common tumor markers in lung cancer, lung squamous cell carcinoma squamous cell carcinoma antigen (SCC) increased significantly, but lung cancer, small cell lung cancer also increased. Most had no specific tumor markers, cross-reactivity between each other, occasionally in some benign diseases and acute and chronic inflammation, it can not be used as screening or diagnostic evidence, only as a secondary diagnosis, determine the efficacy of supplementary indicators, some benign diseases such as pneumonia, influenza, etc., CEA may be slightly increased. General 10 — 15 days return to normal, do not worry too much.

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