Cryotherapy of liver cancer

By | April 17, 2012

Frozen liver cancer treatment, cryotherapy in the treatment of abdominal viscera had the potential role of the tumor to draw attention. As part of liver resection for the treatment of primary liver cancer or metastatic liver cancer is often difficult, people became interested in cryosurgery.
Clinical application showed that this technology is very safe and have a certain effect. From 1973 to 1987, 60 cases of liver cancer at the Stanford School of Clinical Medicine received cryotherapy, some patients received surgical resection and perfusion artery ligation and cytotoxic drugs, 5-year survival rate of 15.6% after surgery, the tumor 5cm below 5-year survival rate of 37.5%. Clinical defects tend to heat combined with chemotherapy or radiotherapy applications.
Frozen liver cancer treatment, heat tolerance is a hot and some of the other cytotoxic agents on the heat-induced resistance in non-hereditary, it can increase the survival of cells on heat resistance. Although the heat tolerance in the clinical treatment of not completely understood, but it certainly is that the thermal tolerance is the effect of hyperthermia negative factors, so the sub-sub-1 per day heating method is not appropriate.
Now commonly used in clinical hyperthermia is 2 times a week, each time interval 72–96 hours, and must ensure that the heating treatment time for 1 – 2 hours, the tumor temperature above 42'C time than 60 minutes order to achieve better results. When combined with radiotherapy, radiotherapy 1 time per day, 5 times a week, heat 2 times a week, duration and time of the tumor temperature above 42C can control 40 —– 60 minutes and 30 minutes.
Frozen liver cancer treatment, hyperthermia on the sensitization effect of anticancer drugs, and the heat treatment temperature. Some anti-cancer drugs, such as melted agent, even at low temperature (30'C – 41 "C) will enhance its anticancer effects, and antitumor effect of increasing temperature increases. There are some anticancer drugs, such as bleomycin, at a lower temperature (39 "C – 40" C) increased when the anti-cancer effect is not obvious, and 43'C showed a strong time effect. Most of sensitizing cancer the role of the ideal temperature is 42 "C – 43" C, such as 5FU, DDP, MMC and so on. There are some anticancer drugs, drugs such as doxorubicin, heated to 42 "C – 43" C, the initially Drug effect was a transient increase, followed by cells of drug resistance.

Leave a Reply

Your email address will not be published. Required fields are marked *