Many tumors may be sensitive to chemotherapy by increasing the dose of chemotherapy to improve treatment.Cancer stem cell transplantation, however, increased intensity of chemotherapy, blood on the body – also increase the damage immune function, leading to repeated infections and the spread of residual cancer cells. Hematopoietic stem cell transplantation may be rapid recovery of hematopoiesis – immune function, for the lifting of high-dose chemotherapy-induced blood – the immune dysfunction and prolong survival time of patients has a positive effect.
Hematopoietic stem cells not only in the bone marrow, embryonic liver, peripheral circulation of blood, umbilical cord blood is rich in hematopoietic stem cells. Therefore, the concept of hematopoietic stem cell transplantation is not only bone marrow transplantation. According to different sources of hematopoietic stem cells, there are clinical bone marrow transplantation, peripheral blood stem cell transplantation, umbilical cord blood transplantation and fetal liver transplantation. Modern studies suggest that peripheral blood stem cells were mobilized both CDt or CFU-GM, the content of the CD is better than bone marrow beans, CFU-GM. Therefore, autologous and allogeneic peripheral blood stem cell transplantation has gradually replaced the autologous and allogeneic bone marrow transplantation, especially in those G-CSF and other cytokines in clinical application, a large number of high-efficiency collection of peripheral blood stem cells become a reality.
Cancer stem cell transplantation, hematopoietic stem cells not only in the treatment of hematologic tumors attention, also updated to expand the high-dose chemotherapy in solid tumors, the treatment concept. Chemotherapy or surgery to reduce the amount of tumor cells to almost eliminate, the use of this method has the potential to improve disease-free survival rate of patients and long-term survival.
Since the late 20th century, 80, peripheral blood stem cell transplantation with high-dose chemotherapy has been recognized as safe and effective new method of cancer treatment since the peripheral blood stem cell transplantation rapidly around the world extensively, its causes, compared with bone marrow transplantation, cancer stem cell transplantation surgery has many advantages:
peripheral blood stem cell collection easy, without anesthesia, the patient is easy to accept.
autologous stem cells into high rate of post-transplant immune reconstitution of hematopoietic function and fast.
peripheral blood stem cell contamination in the less malignant cells.
shortened hospital stay and reduce the financial burden of patients.