Composite of small cell lung cancer (combined small carcinoma of the lung, CSCLC) refers to small cell lung cancer with any organizations, non-small cell carcinoma.
Compound described small cell lung cancer (1) histopathological characteristics and classification: non-small cell carcinoma should be characteristic of the structure, such as squamous cell carcinoma, adenocarcinoma and large cell carcinoma. In any non-small cell carcinoma with small cell carcinoma, small cell carcinoma of the content regardless of how much is attributable to compound small cell lung cancer.
Compound introduced small cell lung cancer, small cell carcinoma of the lung is divided into small cell carcinoma and combined small cell carcinoma, is WHO recommended classification. Common compound in the form of small cell carcinoma are: non-small cell carcinoma; small cell carcinoma and squamous cell carcinoma; small cell carcinoma accompanied by adenocarcinoma and squamous cell carcinoma; small cell carcinoma and large cell carcinoma, this is more a hybrid form rare.
Compound described small cell lung cancer (2) Diagnosis and differential diagnosis: complex of small cell carcinoma, the tumor tissue, non-small cell carcinoma and non-small cell carcinoma of the morphological characteristics, diagnosis is not difficult. But the diagnosis should be with the following tumors.
small cell squamous cell carcinoma (SSCC): This type of cancer are squamous cell carcinoma and small cell carcinoma, similar to small cell carcinoma combined small cell carcinoma and squamous cell complex. More typical squamous cell carcinoma, without identification. Focus on the identification of small cell parts. Small cell carcinoma of the small cell, larger, more cytoplasm; nucleoli more obvious, does not have nested neuroendocrine organ-like structure, and hierarchical structure with characteristics of squamous cell carcinoma.
large cell neuroendocrine carcinoma (LCNEC): This type of cancer with neuroendocrine differentiation of morphological characteristics, namely: with organ-like nests, cords, rosettes structure; electron microscopy and immunohistochemistry that neuroendocrine differentiation markers complex; large necrosis and high mitotic frequency. The similarities in the small cell carcinoma and large cell complex. LCNEC of the cancer cells but relatively large, abundant cytoplasm, nuclear vacuolization or slightly granular, often nucleolus or nucleoli evident. Small cell carcinoma of the compound in the large cell and small cell exist, which does not have a large cell neuroendocrine morphology and neuroendocrine differentiation markers; and small cells with neuroendocrine differentiation, although the morphological characteristics and neuroendocrine markers, However, compared with LCNEC cells, the cancer volume is small, nucleolus is not obvious.