The direction of diffusion transfer of nasopharyngeal carcinoma
NPC for the Department of Otolaryngology most common malignant tumor. High incidence of malignant tumors in the body accounting for 30.97%, accounting for 78.08% of head and neck malignancies, accounting for 92.99% of upper respiratory tract cancer. NPC has the primary site hidden and difficult to be detected early pathological poorly differentiated, highly malignant, easily was invasive growth and early metastasis and so on. Even if the doctors clinical vigilance is high, can seize the opportunity to be diagnosed and many are late. View from the treatment of nasopharyngeal carcinoma, the early cure rate of up to 70% of NPC, while the later 5-year survival rate of patients with 8% -12%, which shows to enhance the understanding of the disease and improve the early diagnosis of value.
Proliferation of lymph node metastasis of nasopharyngeal carcinoma as the most important direction of the transfer means and location. And there the morning shift, the high incidence, as an Initial symptoms of 40% and the patients had cervical lymph node metastasis while 60% -80% range. Most distant metastases late performance is the result of hematogenous metastasis. Rich in the head and neck blood circulation, where a cervical lymph node metastasis, tumor cells invade the opportunity to a lot of people's congresses vein. Therefore prone to hematogenous metastasis, which may be the rapid development and poor prognosis of NPC one of the reasons.
The direction of diffusion transfer of NPC, NPC has a strong local invasion and early metastases, either directly to its spread in all directions, but also show some preference and regularity. According to the diffusion direction more often, can be divided into upstream type, and mixed down three types. Type also known as intracranial invasion-type upstream to the brain development of the first I, II, V, M symptoms of cranial nerve damage or skull base destruction. This type of lymph node metastases appeared late. Downstream broad-based, also known as metastatic cervical lymph node to lymph node metastasis based, there may be violations of cranial nerve symptoms, mixed and the total of the two types of features.