In the earliest stages, embryo cells have the potential to develop into any type of cell, a state called totipotency. Later, this potency becomes restricted through a process called differentiation…
This update was published in the current issue of the American Journal of Medicine by Hennekens and James E. Dalen, M.D., M.P.H., dean emeritus, University of Arizona College of Medicine and executive director of the Weil Foundation. In a commentary published in Clinical Investigation, Hennekens and David J…
The research team has pinpointed the cancer abnormality to a mutation in a gene called PIK3CA that results in a mutant protein, which may be an early cancer switch. By disrupting the mutated signaling pathway, the Case Western Reserve team, led by John Wang, PhD, inhibited the growth of cancer cells, opening the possibility to new cancer therapies. Their findings, "Gain of interaction with IRS1 by p110 helical domain mutants is crucial for their oncogenic functions," was published on May 2 in the journal Cancer Cell. Cancer arises from a single cell, which has mutated in a small number of genes because of random errors in the DNA replication process…