Clinical manifestations of chronic myeloid leukemia

Chronic myeloid leukemia (chronic myelocytic leukemi-a, CML) is a myeloproliferative diseases, is derived from bone marrow pluripotent hematopoietic stem cell level of clonal hematologic malignancies. Characterized by bone marrow and blood of naive mature myeloid cells in the significant increase, especially in middle and late grain staggering, eosinophil, basophil during mosaic, and many have splenomegaly, or splenomegaly. On the more specific cytogenetic marker chromosome. Annual incidence rate of 1.5 / 10 million, ranking third in all types of leukemia, chronic leukemia, the first, more common in middle-aged men than women, cause unknown, many believe that with benzene and other chemical substances and large dose of radiation exposure. Slow progression, but many died in the blast crisis shortly after. Slow onset of early multiple symptoms. Some patients with high white blood cells, or splenomegaly due to periodic medical examination confirmed the discovery. The main clinical manifestations of chronic myelogenous leukemia are the following:
Clinical manifestations of chronic myeloid leukemia 1. Inductance fatigue in patients with early symptoms, sweating, eating less, weight loss, joint pain, fever, anemia, at the advanced stage, when the more dramatic changes in blood embolism.
Clinical manifestations of chronic myeloid leukemia 2. Hepatosplenomegaly splenomegaly seen in 95% of cases, from mild to severe, splenomegaly occupying the abdominal cavity when 2 / 3 can be extended up to the pelvic pressure caused symptoms, splenomegaly the spleen may occur infarction, inflammation or rupture of the spleen around. 45% of patients had mild swelling of the liver, in advanced cases the skin nodules may have central nervous system invasion and infiltration.
Clinical manifestations of chronic myeloid leukemia 3. Fever, anemia and bleeding little early disease infection, anemia and bleeding obvious blastic phase of the disease emerge.
Clinical manifestations of chronic myeloid leukemia 4. Fundus changes visible vein dilation, filling tortuous. The course of the retina and optic nerve may have papilledema, retinal hemorrhage and exudation with nodules.
/L , , , 5. Other than when the WBC 100X 10 9 / L white blood stasis can occur when there Higher lag syndrome, manifested as tinnitus, dizziness, and even the central nervous system hemorrhage or respiratory distress syndrome. Sternal tenderness is more common, particularly when rapid change.


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