Study unveils potential of re-activating tumor fighting proteins within cell
According to the researchers, the human nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 (CRM1) is the sole exportin mediating transport of many multiple tumor suppressor proteins out of the nucleus. Their study aimed to verify the hypothesis that CRM1 inhibition could be beneficial for the treatment of prostate cancer metastases, which was achieved by testing the effects of the orally available, potent and selective, clinical stage SINE compound KPT 330. "Although the class of compounds used in our studies — SINEs or Selective Inhibitors of Nuclear Export — have just recently entered early clinical testing, our results suggest that these agents could be active in patients with androgen-independent prostate cancer," commented study’s lead author Dr. …