Cidofovir is an anti-viral drug that is effective against several viruses, including the human papilloma virus (HPV), which is implicated in the onset of cervical cancer. It targets the cancer-causing proteins (oncoproteins) produced by HPV. These oncoproteins interfere with the action of other proteins that control genome stability and cell death, and so, when cells are infected with HPV they become resistant to dying. …
In bean sprouts, a collection of amino acids known as a protein complex allows them to grow longer in the darkness than in the light. …
ASPS tumor cells contain a chromosomal translocation — strands of DNA from two chromosomes trade places. The two strands fuse together to create a new gene, ASPSCR1-TFE3 that functions differently than either “parent” gene…
The novel research shows that brain metastases have dense concentrations of tumour infiltrating lymphocytes, providing an immunoactive environment. Moreover, both primary and secondary brain cancers often exhibit high expression of the immunosuppressive factor programmed cell death ligand 1 (PDL1), which can be inhibited by new treatments, thus activating the immune system. …
The findings are published online in Lancet Oncology. Study co-leads Dr. Robert Bristow, a clinician-scientist at Princess Margaret Cancer Centre, and Dr. Paul Boutros, an investigator at the Ontario Institute for Cancer Research, report that the gene test provides a much-needed quick and accurate tool to determine with greater precision the men who will do well with local treatment only (surgery or radiation), and those who will need extra treatment (chemotherapy and hormone therapy) to ensure the cancer is completely eradicated. …
The catalysts behind the formation of these deadly metastatic tumors are believed to be cancer cells that are launched into the bloodstream from the original site of the cancer. Researchers are very interested in leveraging these circulating tumor cells, or CTCs, which have the potential to allow the properties of a tumor to be better understood without a biopsy, and may also help physicians recognize how aggressive a tumor is and whether it is likely to cause metastatic disease. …
Lead investigator Ahmad Haider, MD, PhD, urologist, Bremerhaven, Germany, states, “Although considerable evidence exists indicating no relationship between testosterone and increased risk of developing PCa, decades of physician training with the notion that testosterone is fuel for PCa made it difficult to dispel such fallacy and the myth continued to persist. …
The immune system is designed to remove things not normally found in the body. Cells undergoing change, e.g…
“One of the biggest hurdles in cancer immunotherapy is the discovery of appropriate cancer targets that can be recognised by T-cells,” said Singh, who is scientific coordinator of the EU-funded GAPVAC phase I trial which is testing personalised vaccines in glioblastoma, the most common and aggressive brain cancer. “In the GAPVAC trial we will treat glioblastoma patients with vaccines that are ideal for each patient because they contain personalised antigens.”1 For all patients in the GAPVAC study, researchers will identify genes expressed in the tumour, peptides presented on the human leukocyte antigen (HLA) receptor (i.e…
More than just a “cosmetic issue,” breast asymmetry can have negative psychological and emotional effects, according to the study by ASPS Member Surgeon Dr. Brian I. Labow and colleagues of Boston Children’s Hospital…