A switch to dampen malignancy
“We were trying to identify molecular switches that control the plasticity of epithelial cells,” says Ludwig Oxford director Xin Lu, who led the study with Yajun Guo of The Second Military Medical University in Shanghai, China. “Such plasticity is a hallmark of cancer. In order to metastasize, a settled cancer cell must loosen its structure, wiggle free from its confines, travel to another part of the body and, once there, settle down to form a colony…