Genetic variant that increases testicular cancer risk in caucasians evolved to protect light skin
"The genetic risk factor we identified is associated with one of the largest risks ever reported for cancer," says study author Douglas Bell of the National Institute of Environmental Health Sciences at the National Institutes of Health. "We think it might prove useful for identifying individuals at the highest risk for cancer or who might benefit from preventive or therapeutic treatments." About half of human cancers are associated with mutations in the p53 gene, which regulates vital cell functions as well as tumor formation in many tissues. Because p53 must activate a wide range of genes to influence cancer-related signaling pathways, Bell and Gareth Bond of the University of Oxford and the Ludwig Institute for Cancer Research speculated that cancer risk could be associated with genetic variation in p53-binding sites. …