Potential new treatments for acute myeloid leukemia
Both research teams, comprising international scientists from Singapore, United States, Austria, Italy, Netherlands, United Kingdom and Sweden and the Czech Republic, were led by Professor Daniel Tenen, Director, Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS). Breakthrough study validates Sox4 as potential therapeutic target In this breakthrough study, the researchers discovered, for the first time, a molecular target for CEBPA mutations by demonstrating that targeting Sox4 effectively perturbs the major leukemogenic phenotypes in human patient samples of mutated CEBPA AML. These findings were first published in the leading scientific journal Cancer Cell on 11 November 2013. …