The new system, called a tumor-microenvironment-on-chip (T-MOC) device, will allow researchers to study the complex environment surrounding tumors and the barriers that prevent the targeted delivery of therapeutic agents, said Bumsoo Han, a Purdue University associate professor of mechanical engineering. …
The approach fills a gap in current analyses. Complex diseases like cancer usually arise from complex interactions among genetic and environmental factors. When many such combinations are studied, identifying the relevant interactions versus those that reflect chance combinations among affected individuals becomes difficult. In this study, the investigators developed a novel approach for evaluating the relevance of interactions using a Bayesian hierarchal mixture framework…
Complex mechanisms in healthy cells normally protect us from developing cancer. …