The researchers showed that chromosomal instability — which is a hallmark of rapidly dividing cancer cells — makes them stressed and vulnerable to mild metabolic disruption. Metabolism is the normal process by which the body turns food into energy…
“Screening recommendations for this age group continue to be debated,” said Bonnie N. Joe, M.D., Ph.D., associate professor in residence and chief of women’s imaging at University of California, San Francisco (UCSF)…
“Rather than being one of many factors, vitamin D could have a regulative role in the development of SAD,” said Alan Stewart of the University of Georgia College of Education. An international research partnership between UGA, the University of Pittsburgh and the Queensland University of Technology in Australia reported the finding in the November 2014 issue of the journal Medical Hypotheses. Stewart and Michael Kimlin from QUT’s School of Public Health and Social Work conducted a review of more than 100 leading articles and found a relationship between vitamin D and seasonal depression…
More than half (53 per cent) of 1,700 people who completed a health questionnaire said they had experienced at least one red-flag cancer ‘alarm’ symptom during the previous three months. But only two per cent of them thought that cancer was a possible cause…
“Clinicians need to think hard about screening all their triple-negative patients for mutations because there is a lot of value in learning that information, both in terms of the risk of recurrence to the individual and the risk to family members. In addition, there may be very specific therapeutic benefits of knowing if you have a mutation in a particular gene,” says Fergus Couch, Ph.D., professor of laboratory medicine and pathology at Mayo Clinic and lead author of the study. The study found that almost 15 percent of triple-negative breast cancer patients had deleterious (harmful) mutations in predisposition genes. The vast majority of these mutations appeared in genes involved in the repair of DNA damage, suggesting that the origins of triple-negative breast cancer may be different from other forms of the disease. …
“Clinicians need to think hard about screening all their triple-negative patients for mutations because there is a lot of value in learning that information, both in terms of the risk of recurrence to the individual and the risk to family members. In addition, there may be very specific therapeutic benefits of knowing if you have a mutation in a particular gene,” says Fergus Couch, Ph.D., professor of laboratory medicine and pathology at Mayo Clinic and lead author of the study. The study found that almost 15 percent of triple-negative breast cancer patients had deleterious (harmful) mutations in predisposition genes. The vast majority of these mutations appeared in genes involved in the repair of DNA damage, suggesting that the origins of triple-negative breast cancer may be different from other forms of the disease. …
“Because this work shows we can dramatically reduce metastasis in pre-clinical models, and because the drug is already FDA approved for HIV treatment- we may be able to test soon whether this drug can block metastasis in patients with prostate cancer,” says Richard Pestell, M.D., Ph.D., MBA, Director of the Sidney Kimmel Cancer Center at Thomas Jefferson University and senior author on the study. The work builds on previous research from Dr. Pestell’s lab that showed in 2012 that CCR5 signaling was key in the spread of aggressive forms of breast cancer to the lungs…
A team led by University of Alberta biochemistry professor David Brindley found that inhibiting the activity of an enzyme called autotaxin decreases early tumour growth in the breast by up to 70 per cent. …
The study appears Dec. …
TNBC is deadly because, unlike other types of breast cancers such as estrogen receptor (ER) positive or HER2 amplified breast tumours which have effective targeted therapy, TNBC tumours do not respond to targeted therapy. Breast cancer has many subtypes, each with its own genetic makeup. …