Computed Tomography (CT) screening can identify lung tumors while they are still treatable, and the US National Lung Screening Trial (NLST) found that annual screening of high-risk smokers can reduce lung cancer mortality by 20%. The best way to identify those at high risk remains an important question. …
The research was led by Dr Alex J Mitchell, consultant psychiatrist in the Department of Cancer Studies, University of Leicester. Studies have previously shown there is a higher mortality rate due to cancer in people with mental illness, perhaps because of high rates of risk factors such as smoking…
Breasts are considered dense if they have a lot of fibrous or glandular tissue but not much fatty tissue. Research has shown that dense breasts are more likely to develop cancer, a problem compounded by the fact that cancer in dense breasts can be difficult to detect on mammograms. Other imaging modalities like ultrasound and MRI are often used to help find cancers that can’t be seen on mammograms, but both modalities have higher rates of false-positive findings, which are suspicious findings that turn out not to be cancer. This higher false-positive rate often results in more tests and unnecessary biopsies, making MRI and ultrasound expensive to implement in high-volume screening programs, according to study lead author Per Skaane, M.D., Ph.D., from the Department of Radiology at Oslo University Hospital in Oslo, Norway. …
TNBC accounts for 15% to 20% of breast cancer cases, and patients have shorter recurrence-free survival (RFS) and breast cancer-specific survival (CSS) relative to other major subgroups. It is likely that different subtypes of TNBCs exist, and the heterogeneity may be responsible for a wide variation in response to treatment. “Predictive biomarkers for therapeutic response prediction and novel therapeutic targets that address distinct biological features of TNBC subgroups are needed for these patients,” says Lorenzo F. Sempere, PhD, head of the Laboratory of microRNA Diagnostics and Therapeutics at Van Andel Research Institute in Grand Rapids, MI. …
“Screening recommendations for this age group continue to be debated,” said Bonnie N. Joe, M.D., Ph.D., associate professor in residence and chief of women’s imaging at University of California, San Francisco (UCSF)…
Reflux can be a common side effect of chemotherapy or radiation treatment for head and neck cancer. Doctors at the University of Michigan frequently prescribe two types of antacids – proton pump inhibitors or histamine 2 blockers – to help treat this side effect. The researchers looked at 596 patients who were treated for head and neck cancer…
This finding will provide important clues to understanding the process of tumor formation and the mechanism for suppressing cancer since the abnormal cell division marks the early events of cancer development. For the first time, the IBS research team has found that during mitosis, the cellular dsRNAs activate PKR, an enzyme previously known as a trigger of immune response during virus infection. Activated PKR then regulates protein synthesis and orchestrates mitotic processes…
Gorlin syndrome causes an increased risk of developing cancers of the skin and, rarely, in the brain. …
Breasts are considered dense if they have a lot of fibrous or glandular tissue but not much fatty tissue. …
TNBC accounts for 15% to 20% of breast cancer cases, and patients have shorter recurrence-free survival (RFS) and breast cancer-specific survival (CSS) relative to other major subgroups. It is likely that different subtypes of TNBCs exist, and the heterogeneity may be responsible for a wide variation in response to treatment. “Predictive biomarkers for therapeutic response prediction and novel therapeutic targets that address distinct biological features of TNBC subgroups are needed for these patients,” says Lorenzo F. …