“Screening recommendations for this age group continue to be debated,” said Bonnie N. Joe, M.D., Ph.D., associate professor in residence and chief of women’s imaging at University of California, San Francisco (UCSF)…
TNBC accounts for 15% to 20% of breast cancer cases, and patients have shorter recurrence-free survival (RFS) and breast cancer-specific survival (CSS) relative to other major subgroups. It is likely that different subtypes of TNBCs exist, and the heterogeneity may be responsible for a wide variation in response to treatment. “Predictive biomarkers for therapeutic response prediction and novel therapeutic targets that address distinct biological features of TNBC subgroups are needed for these patients,” says Lorenzo F. …
The researchers showed that chromosomal instability — which is a hallmark of rapidly dividing cancer cells — makes them stressed and vulnerable to mild metabolic disruption. Metabolism is the normal process by which the body turns food into energy…
According to researchers from the Joslin Diabetes Center and the Department of Medicine at Harvard Medical School, “Since insulin resistance alters the metabolic status in the affected individuals, its presence in women during pregnancy has the potential to be detrimental to growth and metabolism in the offspring. Thus, insulin resistance directly impacts pregnant women and also their offspring.” The research team — which included Sevim Kahraman, Ercument Dirice, Dario DeJesus, Jiang Hu and Rohit Kulkarni — used a mouse model of insulin resistance to find out how it affects metabolism and endocrine pancreas development in the offspring. Insulin is a hormone created in the beta cells (β-cells) of the pancreas. …
“Rather than being one of many factors, vitamin D could have a regulative role in the development of SAD,” said Alan Stewart of the University of Georgia College of Education. An international research partnership between UGA, the University of Pittsburgh and the Queensland University of Technology in Australia reported the finding in the November 2014 issue of the journal Medical Hypotheses. Stewart and Michael Kimlin from QUT’s School of Public Health and Social Work conducted a review of more than 100 leading articles and found a relationship between vitamin D and seasonal depression…
More than half (53 per cent) of 1,700 people who completed a health questionnaire said they had experienced at least one red-flag cancer ‘alarm’ symptom during the previous three months. But only two per cent of them thought that cancer was a possible cause…
GABA, or gamma-aminobutryic acid, is an amino acid produced by the same beta cells that make and secrete insulin. Drs…
“Clinicians need to think hard about screening all their triple-negative patients for mutations because there is a lot of value in learning that information, both in terms of the risk of recurrence to the individual and the risk to family members. In addition, there may be very specific therapeutic benefits of knowing if you have a mutation in a particular gene,” says Fergus Couch, Ph.D., professor of laboratory medicine and pathology at Mayo Clinic and lead author of the study. The study found that almost 15 percent of triple-negative breast cancer patients had deleterious (harmful) mutations in predisposition genes. The vast majority of these mutations appeared in genes involved in the repair of DNA damage, suggesting that the origins of triple-negative breast cancer may be different from other forms of the disease. …
“Clinicians need to think hard about screening all their triple-negative patients for mutations because there is a lot of value in learning that information, both in terms of the risk of recurrence to the individual and the risk to family members. In addition, there may be very specific therapeutic benefits of knowing if you have a mutation in a particular gene,” says Fergus Couch, Ph.D., professor of laboratory medicine and pathology at Mayo Clinic and lead author of the study. The study found that almost 15 percent of triple-negative breast cancer patients had deleterious (harmful) mutations in predisposition genes. The vast majority of these mutations appeared in genes involved in the repair of DNA damage, suggesting that the origins of triple-negative breast cancer may be different from other forms of the disease. …
A team led by University of Alberta biochemistry professor David Brindley found that inhibiting the activity of an enzyme called autotaxin decreases early tumour growth in the breast by up to 70 per cent. …