Changes in radiation dose fractionation scheme, clinical, and tumor cell proliferation kinetics study shows that conventional fractionated radiotherapy in esophageal cancer survival Stem cell esophageal carcinoma accelerated repopulation is one of the main local failure to overcome accelerated repopulation of tumor cells can increase esophageal cancer the control rate. Hyperfractionated accelerated radiotherapy (daily exposure to two or more, each dose is less than conventional total dose with conventional fractionation split, the total course of treatment shorter than the conventional fractionation) may be increased, including some of esophageal cancer, including Yao's control rate. Although the increase in acute radiation reaction, but not significantly increase feeding late normal tissue radiation injury. Currently, the preliminary results of clinical studies show that the left continued accelerated hyperfractionated (HART) and post-course accelerated hyperfractionated (LeAF) improved local control rate of esophageal cancer and survival, without significant increase in late normal tissue radiation injury.
Radiation dose fractionation scheme to change 1) continuous accelerated hyperfractionated
1991 Peng Kaigui reported the results of a randomized study, daily exposure to 2 times per 1.5Gy, 23 irradiation total dose 51Gy, compared with conventional fractionation (60_70) Gyl7 week, 2-year survival rate from 18.5% to 44.4% ( P <0.05). Reported in 1994, Meng Guangdian compared with conventional fractionation (60_70) Gy, accelerated hyperfractionation.
(1.4GyBid, 75Gy_82Gy/6_7 week) 1 year survival rate higher than the conventional fractionation group (77.8% vs 50%). Japan reported 64 cases of Kik mountain h conventional fractionated radiotherapy of esophageal cancer 5-year survival rate was 13.9%, and 60 cases of morning light 2Gy, the afternoon light 1% 1_1.2Gy, 5 accelerated hyperfractionated irradiation 62_64Gy The 5-year survival rate 31%, significantly higher than that of conventional fractionation group (P <0.05).
Radiation dose fractionation scheme to change 2) late-course accelerated hyperfractionation
In 1988 the author directly under the tumor cell colonization dynamics of esophageal cancer and esophageal cancer after radiotherapy open Shan course accelerated hyperfractionation radiotherapy plan, that in the first 4 and a half weeks of radiotherapy to conventional fractionated radiotherapy, each 1.8Gy, day 1, According to 5 times per week, 23 days exposure to drama (41.4Gy/23 times, a total of 4.6 weeks), to exposure to 2 times a day, every 1.5Gy, asked IWi4 to hour, day radiation treatment of the 9 27Gy, total 68.4Gy / 41, 6.418. And in April 1988 to April 1990 a prospective randomized study. Listen segmentation results with the conventional group, tumor 5-year local control rate of 26.2% increased to 58.8
(P <0.01), 5-year survival rate from 14.3% to 32.6% (P <O.05). October 1991 to May 1993 Provincial Tumor Hospital, from April 1992 to June 1994 in Anhui Province Tumor Hospital course accelerated radiotherapy for esophageal cancer than conventional radiotherapy has doubled, and the authors report the results of the same.