Tag Archives: tcga

Promising prognostic biomarker candidates for ovarian cancer uncovered

The first study establishes an association of this often-deadly cancer with the immune system and clarified the role of a class of immunogenic tumor antigens known as cancer testis (CT) antigens, and the second reports new evidence that certain molecular interactions influence ovarian cancer prognosis. In context with recent evidence that the immune system can potently inhibit the growth of cancer cells, these novel findings may enable development of a new strategy for identifying those patients most likely to benefit from particular targeted therapies. “There is a lot of interest right now in what to do with the human genome,” says Kevin Eng, PhD, an Assistant Professor of Oncology in the Department of Biostatistics and Bioinformatics at RPCI who was first author on both studies. …

Powerful new system for classifying tumors revealed

“It’s only ten percent that were classified differently, but it matters a lot if you’re one of those patients,” said senior author Josh Stuart, a professor of biomolecular engineering at UC Santa Cruz. Stuart helped organize the study as part of the Pan-Cancer Initiative of the Cancer Genome Atlas (TCGA) project…

Cancer genomics hub adds childhood cancer data

A UCSC team led by bioinformatics expert David Haussler established CGHub in 2012 to manage primary sequence data from all of NCI’s cancer genomics research programs. These programs, which aim to improve cancer treatment by identifying the genetic drivers of cancer, require massive amounts of data to be shared among researchers throughout the country. …