Tag Archives: project

Geme mutation potential target for diagnosis, treatment of insulinoma

Pancreatic neuroendocrine tumors are classified into functional and nonfunctional tumors by hormone secretion and clinical symptoms. Functional PNETs are mainly represented by insulinoma, which secrete insulin independent of glucose and cause hypoglycemia. The major genetic alterations in insulinomas are still unknown. …

Genetic flaw in males triggers onset of liver cancer, diabetes

The research, published in the online issue of Cancer Cell, found that when the NCOA5 gene, present in both men and women, was altered in male mice to a deficient level, a spontaneous reaction occurred producing cells that can lead to hepatocellular carcinoma, a type of liver cancer found to be two-to-four times more prevalent in men than women. Findings also showed that prior to cancer development there were occurrences of glucose intolerance, a prediabetic condition that is believed to increase the risk of type 2 diabetes in humans. …

Resistant against the flu

Whether it is H1N1, H5N1 or H7N9: The flu virus influenza A exists in many different types as its two coating proteins haemagglutinin (HA) and neuraminidase (NA) can be combined in various ways. Theoretically, more than 100 different pairings are possible. Additionally, the coating proteins themselves can undergo changes. This variability is one of the reasons why the flu vaccination has to be renewed every year…

A cost-effective way toward personalized cancer drugs

In treating many types of cancer, doctors often use combi-nation of chemotherapy with other treatments. The cytostatic agents used are designed to target faster growing cancer cells. But there is little consistency in how different patients respond to the various treatments: even when dealing with the same type of tumor, there are vast differences in tumor cell reaction to a given treatment…