The research, published in the journal Nature Communications, provides evidence for how these particular melanoma cells help tumors resist drugs designed to block blood vessel formation. “For a long time the hope has been that anti-angiogenic therapies would starve tumors of the nutrients they need to thrive, but these drugs haven’t worked as well as we all had hoped,” said Andrew C…
The discovery that the protein CHT7 is a likely repressor of cellular quiescence, or resting state, is published in the current issue of the Proceedings of the National Academy of Sciences. This cellular switch, which influences algae’s growth and oil production, also wields control of cellular growth — and tumor growth — in humans…
Their findings are the subject of a report, “More Skin, More Sun, More Tan, More Melanoma,” in the October 6, 2014 issue of the American Journal of Public Health. …
“The bioactive compounds in Camelina sativa seed, also known as Gold of Pleasure, are a mixture of phytochemicals that work together synergistically far better than they do alone. This seed meal is a promising nutritional supplement because its bioactive ingredients increase the liver’s ability to clear foreign chemicals and oxidative products. And that gives it potential anti-cancer benefit,” said Elizabeth Jeffery, a U of I professor of nutritional toxicology. Oilseed crops, including rapeseed, canola, and camelina, contain some of the same bioactive ingredients — namely, glucosinolates and flavonoids — found in broccoli and other cruciferous vegetables and in nearly the same quantities, she noted. …
In a major study, Dr Ian Frayling from Cardiff University’s School of Medicine and researchers from the University of Exeter’s Medical School assessed the effectiveness of introducing a UK-wide screening program for a genetic condition known as Lynch Syndrome. Lynch syndrome is caused by changes in genes which check the spelling in DNA. The condition increases the risk of people developing cancer, particularly bowel cancer and cancers of the womb and ovaries later in life. …
The San Diego-based company has developed an experimental treatment, called ZMapp, which contains antibodies manufactured in plants. …
Scientists at the University of Michigan and the U-M Health System recently discovered a protein mutation that causes the devastating disease dyskeratosis congenita, in which precious hematopoietic stem cells can’t regenerate and make new blood. People with DC age prematurely and are prone to cancer and bone marrow failure. But the study findings reach far beyond the roughly one in 1 million known DC patients, and could ultimately lead to developing new drugs that prevent cancer from spreading, said Jayakrishnan Nandakumar, assistant professor in the U-M Department of Molecular, Cellular, and Developmental Biology. …
The multi-centre, double-blind, randomised, phase 3 trial compared oral dabrafenib (150 mg twice daily) and oral trametinib (2 mg once daily) combination therapy with oral dabrafenib (150 mg twice daily) and placebo. …
The University of Illinois team reports its findings in the journal Oncogene. Estrogen pre-activates the unfolded-protein response (UPR), a pathway that normally protects cells from stress, the researchers report. The UPR spurs the production of molecular chaperones that prepare cells to divide and grow. Without chaperone proteins to do the work of folding and packaging other proteins, cells — including cancer cells — cannot divide. …
The University of Illinois team reports its findings in the journal Oncogene. …