Tag Archive harbor

Study revises theory of how PTEN, a critical tumor suppressor, shuts off growth signals

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Today, scientists at Cold Spring Harbor Laboratory (CSHL) publish new evidence explaining precisely how the protein encoded by PTEN (called PTEN) works — specifically, how it is recruited to particular locations in our cells where pro-growth signals need to be shut off. The new evidence, assembled by a team led by CSHL Associate Professor Lloyd Trotman, contradicts a long-held assumption about PTEN function, and could help scientists design more effective drugs to counteract cancer’s hallmark trait, uncontrolled cellular growth…

How premalignant cells can sense oncogenesis, halt growth

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Since the 1980s, scientists have known that mutations in a human gene called RAS are capable of setting cells on a path to cancer. Today, a team at Cold Spring Harbor Laboratory (CSHL) publishes experiments showing how cells can respond to an activated RAS gene by entering a quiescent state, called senescence. CSHL Professor Nicholas Tonks and Benoit Boivin, now a University of Montreal Assistant Professor, co-led a team that traced the process in exquisite detail. …

How antioxidants can accelerate cancers, and why they don’t protect against them — ScienceDaily

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source : http://www.sciencedaily.com/releases/2014/07/140710094434.htm