Tag Archives: england

Finasteride: Long-term survival of participants in prostate cancer prevention trial detailed

New findings reported in NEJM on August 15, 2013, based on follow-up of trial participants for up to 18 years, showed that survival of the men on finasteride was equivalent to men who did not take the drug and the reduction in risk of prostate cancer persists. Among nearly 19,000 eligible men who underwent randomization, prostate cancer was diagnosed in 10.5 percent of those in the finasteride group and 14.9 percent of those in the placebo group, a 30 percent reduction in risk…

Scientists identify biomarker to predict immune response risk after stem cell transplants

Although transplant specialists have been able to reduce its impact, graft-versus-host disease remains a leading cause of death among patients who receive a stem cell transplant from another person, known as an allogeneic transplant. Such transplants are used to treat blood and bone marrow cancers such as leukemia and multiple myeloma, often as a last resort…

Thwarting protein production slows cancer cells’ malignant march

From yeast to worms to humans, this stress response and its primary regulator, heat shock factor 1 (HSF1), help normal cells adapt to harsh environments, including the presence of heavy metals, high salt concentrations, low oxygen levels, and of course increased temperatures. "In a perverted twist of fate, cancer cells take advantage of this incredibly ancient survival strategy — the heat shock response — to help them survive despite the best efforts of our own natural defenses, and sophisticated therapeutics, to kill them," says Whitehead Member Susan Lindquist. "And trumping all that, we find it not only helps them survive, it helps them thrive!" Across tumor and cancer types, cancer cells rely on the heat shock response and HSF1 to support the production of vast quantities of proteins and the high-energy demands needed to propel malignancy…

‘Scent device’ could help detect bladder cancer

There are currently no reliable biomarkers to screen patients for bladder cancer in the same way that there are for breast and cervical cancers. Previous research has suggested that a particular odour in the urine could be detected by dogs trained to recognise the scent, indicating that methods of diagnoses could be based on the smell of certain gases. The team have now built a device, called ODOREADER ® that contains a sensor which responds to chemicals in gas emitted from urine…

Scientists discover why man stores no fat under skin

British paracyclist Tom Staniford has discovered he is one of just eight people in the world with a rare syndrome. Staniford, 23, is unable to store fat under his skin, losing all the fat around his face and limbs during childhood (despite) having been born a normal weight, the BBC reports. In spite of his wasted frame, Staniford's body thinks he is obese, meaning he has type 2 diabetes. His hearing also became impaired in his childhood, requiring him to wear hearing aids since the age of 10. Staniford’s condition - MDP syndrome - was not identified until recently, when a research team went to work mapping and analyzing his DNA, in a quest to isolate the gene mutation responsible. This was only possible after a second person with the same condition was found. Using the most recent genome sequencing technology, scientists from England, India, Italy and the US were able to identify the single genetic mutation responsible for the rare condition. “All Tom's features can be explained by this one specific change,” said Exeter University scientist Professor Andrew Hattersley, who believes the genetic mutation would have occurred in Staniford’s father’s sperm very early in Staniford's life. Staniford has not let the condition hold him back from achieving several goals, including being British national paracycling circuit race champion in 2011, as well as a degree in law and French. He hopes to become Paralympic circuit race champion at Rio 2016. Staniford does concede, however, that his condition presents particular challenges to training: “I have just 40 percent of the muscles of an average male. I struggle to metabolize sugar and carbohydrates efficiently due to the diabetes - and I struggle to recover due to lack of immediate fuel sources, low testosterone etc. “My muscles have a very narrow margin of efficiency and they're also tight, stiff and inflexible because I don't have fat to perform that role. “This is why I have to constantly experiment and attempt to find, through trial and error, what works.” Staniford is not one to dwell on the rarity of his condition, but says: “[It] is reassuring to know that there are other people with the condition and that we can lead relatively normal lives.” Click for more at news.au.com.source : http://www.foxnews.com/health/2013/06/18/scientists-discover-why-man-stores-no-fat-under-skin/

‘Undruggable’ cancer may be druggable after all: New target identified

The gene, SALL4, gives stem cells their ability to continue dividing as stem cells rather than becoming mature cells. Typically, cells only express SALL4 during embryonic development, but the gene is re-expressed in nearly all cases of acute myeloid leukemia and 10 to 30 percent of liver, lung, gastric, ovarian, endometrial, and breast cancers, strongly suggesting it plays a role in tumor formation. In work published in the New England Journal of Medicine, two HSCI-affiliated labs — one in Singapore and the other in Boston — show that knocking out the SALL4 gene in mouse liver tumors, or interfering with the activity of its protein product with a small inhibitor, treats the cancer. "Our paper is about liver cancer, but it is likely true about lung cancer, breast cancer, ovarian cancer, many, many cancers," said HSCI Blood Diseases Program leader Daniel Tenen, who also heads a laboratory at the Cancer Science Institute of Singapore (CSI Singapore)…