New technology detects cellular memory, aids in understanding of how diseases such as cancer arise — ScienceDaily
source : http://www.sciencedaily.com/releases/2014/02/140224110144.htm
Tag Archives: action
Natural compound attacks HER2 positive breast cancer cells — ScienceDaily
source : http://www.sciencedaily.com/releases/2014/02/140217200755.htm
First observation of a human HAT, key proteins in numerous pathologies — ScienceDaily
source : http://www.sciencedaily.com/releases/2014/02/140211113835.htm
3-D mapping biopsy finds three times the prostate cancer of ultrasound-guided biopsy — ScienceDaily
source : http://www.sciencedaily.com/releases/2014/02/140204154308.htm
Melatonin shows potential to slow tumor growth in certain breast cancers — ScienceDaily
source : http://www.sciencedaily.com/releases/2014/01/140128103117.htm
Better guidelines, coordination needed for prostate cancer specialists — ScienceDaily
source : http://www.sciencedaily.com/releases/2013/12/131209143254.htm
Leukemia: mode of action of a targeted treatment clarified
The PML/RARA protein causes the proliferation of cancer cells in patients affected by acute promyelocytic leukemia. Existing targeted treatments combining a hormone — retinoic acid — and a poison — arsenic — result in permanent recovery for the majority of patients, without us having a precise understanding of their action on cancer cells. Previous work by Prof Hugues de Thé’s team has shown that the combination of arsenic and retinoic acid causes destruction of the PML/RARA protein and the elimination of leukaemic stem cells…
New cell mechanism discovery key to stopping breast cancer metastasis
"Genetic mutations do not drive this mechanism," said Alana Welm, PhD, senior author of the study, associate professor in the Department of Oncological Sciences, and an investigator at Huntsman Cancer Institute. "Instead, it’s improper regulation of when genes turn on and off." The new discovery focuses on a protein called RON kinase (RON), which signals some areas of tumor cell DNA to become active…
Potential therapeutic target for incurable, rare type of soft-tissue cancer
In the study, published online in Cell Reports, scientists found that inhibiting the action of a protein called BRD4 caused cancer cells to die in a mouse model of malignant peripheral nerve sheath tumors (MPNSTs). "This study identifies a potential new therapeutic target to combat MPNST, an incurable type of cancer that is typically fatal," said Dr. …
Rock and rho: Proteins that help cancer cells groove
"High levels of RhoA and ROCK1 were known to worsen outcomes for breast cancer patients by endowing cancer cells with the ability to move, but the trigger for their production was a mystery," says Gregg Semenza, M.D., Ph.D., the C. Michael Armstrong Professor of Medicine at the Johns Hopkins University School of Medicine and senior author of the article. "We now know that the production of these proteins increases dramatically when breast cancer cells are exposed to low oxygen conditions." To move, cancer cells must make many changes to their internal structures, Semenza says. Thin, parallel filaments form throughout the cells, allowing them to contract and cellular "hands" arise, allowing cells to "grab" external surfaces to pull themselves along. …