Routine treatment of breast cancer

By | January 20, 2012

More breast cancer treatment, including surgery, radiation therapy, chemotherapy, endocrine therapy. Currently most used surgical combined therapy.
Routine treatment of breast cancer (1) chemotherapy: chemotherapy cancer treatment is an important systemic adjuvant therapy, commonly used paclitaxel (or docetaxel), epirubicin, cisplatin and other joint therapy.
Routine treatment of breast cancer (2) radiation therapy: often used after surgery to prevent local recurrence. Radiation therapy for advanced breast cancer, the tumor can shrink, and some even can not be in surgery for operable breast cancer metastases. Isolated local recurrence for lesions and bone metastases of breast cancer have some palliative effect. But for early breast cancer without lymph node metastasis do, do not routinely radiotherapy, to avoid damaging the body's immune function.
Breast conventional therapy (3) endocrine treatment: surgery or radiation therapy should not be any of primary advanced breast cancer, determination of estrogen receptor-positive, endocrine therapy alone or in combination.

Adjuvant endocrine treatment of breast cancer and its mechanism can be divided into three categories:
selective estrogen receptor modulator agents, including derivatives of estrogen toremifene glue and three phenoxy (toremifene), steroid complex (fulvestrant), other non-steroidal compound ( raloxifene). aromatase inhibitor, currently in third-generation aromatase inhibitors in postmenopausal breast cancer patients as adjuvant endocrine therapy is the most studied of anastrozole, letrozole and exemestane. ovariectomized, there are mainly three methods: surgical castration (surgical removal of ovaries), radiation and drug-induced castration castration. Ovariectomized drugs are goserelin, triptorelin, and leuprolide. Only goserelin in 2002 by the U.S. FDA approved for advanced breast cancer in premenopausal endocrine therapy, usage is 3.6mg once a month, subcutaneous administration. 15 years of follow-up results of foreign shows that in the same conditions, plus the recurrence rate in ovariectomized group significantly lower than that without using ovariectomized group were 47.3%, 51.6%; there are significant differences in mortality, 40.3%, 43.5%.
2005 consensus that endocrine therapy for premenopausal breast cancer patients sensitive to the three phenoxy adhesive is still the standard adjuvant endocrine therapy, ovarian castration as a three-phenoxy plastic contraindications adjuvant endocrine treatment of patients. Although the lack of rubber on the three co-phenoxy concluding ovariectomized efficacy data, but for the very young and chemotherapy in high-risk patients can not be induced in ovariectomized premenopausal role of high-risk patients, the use of plastic in ovariectomized combined treatment of the three phenoxy is an appropriate secondary treatment. For further ovariectomized chemotherapy combined with other endocrine therapy is still inconclusive.
Routine treatment of breast cancer (4) surgical treatment: radical breast surgery over a century old, is still the primary means of breast cancer treatment, and no axillary lymph node metastasis in early breast cancer the most satisfactory effect. However, due to people's aesthetic needs and the high quality of life, breast-conserving surgery has become the main method, can be taken to the method of local tumor excision, with postoperative radiotherapy and chemotherapy.

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