Drug classification and treatment of tumors

By | April 26, 2012

Drug classification and treatment of tumors, cancer is the human body in a variety of internal and external factors caused by the action of tumor caused by abnormal proliferation of cells in the formation of new biological, clinical manifestations of the limitations of mass. Tumor cells are immature cells from the human body transformed from that of normal cells with abnormal morphology different, metabolism and function. The body except the hair, teeth and fingers (toes) A, almost all of the tissues, organs, tumors can occur.
With the continuous growth of tumor in the patient population, cancer treatment has become more difficult, but the efficacy of cancer therapy, or worthy of recognition. Cancer drug therapy is classified as:
1, cytotoxic drugs
(1) on the chemical structure of DNA alkylating agent, such as nitrogen mustard class of drugs, urinary nitrite class of platinum methanesulfonate ester compounds such as cisplatin, carboplatin and oxaliplatin, etc. mitomycin (MMC).
(2) drugs that affect nucleic acid synthesis
Dihydrofolate reductase inhibitors such as methotrexate (MTX) and Alimta, etc.;
Nucleoside synthesis inhibitors such as the thymus fluorouracil (5FU, FT-207, capecitabine), etc.;
Purine nucleoside synthesis inhibitors such as 6 – mercaptopurine (6-MP) and 6-TG, etc.;
Ribonucleotide reductase inhibitors such as hydroxyurea (HU), etc.;
DNA polymerase inhibitors such as cytarabine (Ara-C) and gemcitabine (Gemz), etc.;
(3) of drugs acting on DNA transcription
Selective action on the DNA template, inhibition of DNA dependent RNA polymerase, thereby inhibiting drugs such as RNA synthesis: actinomycin D, daunorubicin, doxorubicin, epirubicin, aclarubicin, adriamycin glory and so on.
Drug classification and treatment of tumors (4) major role in the synthesis of drug-tubulin
Paclitaxel, docetaxel, vinblastine, vinorelbine, podophyllotoxin base class, homoharringtonine base.
(5) other cytotoxic
Asparaginase inhibition of protein synthesis mainly
2, biological response modifiers of immune function mainly through inhibition of tumor
Interleukin -2
Thymosin class
3, hormones
Anti-estrogen: Tamoxifen, droloxifene, exemestane and other aromatase inhibitors: aminoglutethimide, Lante Long, letrozole, Ruining De anti-androgen such as: ammonium fluoride which agonist RH-LH / antagonist: Nuolei De, according to that pass and so on.
4, monoclonal antibodies
Rituximab (MabThera) Cetuximab (C225)
Herceptin (Trastuzumab) Bevacizumab (Avastin)
Drug classification and treatment of tumors, 5, and other
Including some of the current mechanism is unknown and further study of the drug, cell differentiation inducing agents such as retinoid, apoptosis inducers, angiogenesis inhibitors.

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