Increasing deterioration of the tumor lesions, tumor metastasis by the late very easy, especially liver metastasis tumors. According to clinical observations, tumor liver metastases ways are: transfer of blood, the lymphatic flow transfer, direct spread of cancer. Among them, the majority of liver metastases due to hematogenous metastasis. Now are summarized in the following:
Cancer liver metastasis pathway (1) hematogenous metastasis
The liver is the largest of intra-abdominal parenchymal organs. Very rich blood supply to the liver, blood volume, blood flow rate, the liver blood supply from the hepatic artery and portal vein composed of two pipeline systems, hepatic blood flow in 25% -30% of the oxygen-rich from the hepatic artery arterial blood, the other 70% -75% return from the collection of the gastrointestinal tract of the portal vein blood, blood by the liver after hepatic artery and portal vein into the very small branch of step by step into the sinus, back through the porous walls of hepatic sinusoid to the central venous sinus, the left end progressively converge to the liver, liver liver the right hepatic vein 3 import inferior vena cava. Through the hepatic artery and portal vein blood sinusoidal, sinusoidal with a single core within the macrophage system and liver Kupffer cell phagocytosis, as if through layers of filters, the bacteria in the blood, pigment and other debris removed. Which contain the blood of cancer cells through the liver, the cancer is very likely to stay in the above circumstances, the liver, and grow together to form metastases.
Cancer liver metastasis pathway (2) the transfer by the lymphatic flow
This way the formation of transfer is transferred through the lymphatic system, common in the gallbladder, lymphatic spread from the gallbladder fossa to the hepatic hilar lymph nodes or lymphatic vessels along the retrograde transfer to the liver. Other gastrointestinal cancer but also through the hepatic portal lymph nodes along the retrograde lymphatic metastasis to the liver. Breast, lung, mediastinal lymph nodes through the hepatic falciform ligament retrograde lymphatic metastasis to the liver.
Cancer liver metastasis pathway (3) direct spread
As the name implies, this transfer is outside the liver tumor to neighboring organs invasive growth, a direct violation of the spread of the liver, common in the stomach , transverse colon, gallbladder, film, and right renal adenocarcinoma, adrenal gland tumor.
Because the liver has two blood system – the system of portal vein and hepatic artery, so blood liver metastasis caused by metastatic cancer, and metastasis via the portal vein into the hepatic artery transfer 2. The portal vein into the liver blood accounted for 70% -75%, while the portal vein is the venous blood returning gastrointestinal tract, it is by the portal vein metastasis, liver cancer, liver cancer, the most important for the majority of the transfer via the portal vein, about the liver metastasis -50% 35%, and its main source is the portal vein drainage area – within the digestive tract and pelvic malignancies, such as stomach, colon, rectum, gallbladder, film adenocarcinoma, uterine cancer, ovarian adenocarcinoma. Transfer of the hepatic artery from the pulmonary metastatic liver cancer and the main circulation of various organs, a common source of lung cancer, breast cancer, kidney cancer, malignant melanoma, nasopharyngeal carcinoma and so on.