Symptoms of Lymphoma

By | May 1, 2012

Symptoms of malignant lymphoma, malignant lymphoma diverse clinical manifestations, because the lymphoid tissue is widely distributed in the body, any part of the lymphoid tissue can be used as the primary site or in the course of the disease have been violated, in different parts of the lesions may manifest as different symptoms. In addition, the advanced malignant lymphoma can also infringe on other parts of the lymphatic tissue, the symptoms even more complicated.
1. Lymph nodes
The superficial lymph nodes as the first symptom accounted for more than 60% of which occurred in the neck accounted for 60% to 80%, followed by axillary accounted for 6% to 20%, 6% to 12% groin, involving the collar, the lymph nodes around the ears, etc. are less.
Lymph nodes often asymmetric, are hard and flexible, no pain, early and do not adhesion, deep lymph nodes, which can cause symptoms of local invasion and oppression.
Mediastinal lymph node involvement can occur in compression syndrome, pulmonary infiltrates, atelectasis, or pleural effusion. Abdominal lymph node involvement (retroperitoneal para-aortic, mesenteric), there may be abdominal pain, low back pain, abdominal mass, bowel and bladder problems, or hematuria. Digestive tract (submucosal) lymphoid tissue involvement may suffer from abdominal pain, diarrhea, abdominal mass, bowel obstruction, blood in the stool, intestinal perforation or malabsorption syndrome. Intestinal lymphoma spread to the order of ileum, cecum, rectum, jejunum, duodenum and colon. Pharyngeal tonsil and lymphoid tissue involvement may occur ring swollen tonsils, nasopharyngeal mass or difficulty breathing, and easy to violations of the stomach and retroperitoneal lymph nodes.
2. Splenic lesions more common in Hodgkin's lymphoma, may have splenomegaly and hypersplenism.
3. Liver disease seen in advanced disease, hepatomegaly and abnormal liver function occurred, some patients may be due to hilar lymph nodes or the liver caused by obstructive cholestasis yellow disease.
4. Confucianism lesions of bone marrow lesions, accounting for about 0 to 15%, the most common in the thoracic and lumbar spine, ribs and skull followed. Manifested as bone pain, pathologic fractures. NHL bone marrow involvement are more common.
5. Skin lesions
Skin lesions can be divided into specific and non-specific. Specific disease or lymphoma of the skin infiltration, the performance of diversity, mass, nodule, invasive plaque, ulcer, Qiu Yan, spot more than men, and occasionally malignant erythroderma. Non-specific inflammatory changes only ordinary disease, manifested as itching, itching Yan, Yan ribbon marks itch and acquired ichthyosis.
Malignant lymphoma of the symptoms 6. Cotton by system diseases
Common with cranial nerve paralysis, headache, epilepsy seizures, increased intracranial pressure, spinal cord compression and paraplegia, can also occur on progressive multifocal leukoencephalopathy and subacute cerebellar degeneration.
Late when the tumor invasion into the area outside the lymphoid tissue, may be a variety of clinical manifestations, such as the liver, yellow disease, bone pain, pathological fracture, breast enlargement, exophthalmos, skin lumps. Pleural effusion, pericardial effusion, pulmonary mass, limb and cranial nerve paralysis, paraplegia (epidural pressure) and so on.
7. Systemic symptoms
(1) heat: Heat can be irregular type, but also the characteristic cycle of a relapsing fever-type (Pel-bstein type), fever may be due to cycle-related tumor cells into the blood.
(2) sweating: Obviously.
(3) weight loss: weight loss within six months per special reasons, more than 10%. Some patients have onset or course of pruritus (with or without skin Yan). Lymphoma symptoms are special in itself with fever, night sweats and weight loss, one in three is considered to have "B" symptoms. Symptoms common to HL than NHL.
General clinical features of HL and NHL, has the following differences:
(1) HL vast majority of the superficial lymph nodes, especially cervical lymph nodes as the first symptom, while the NHL is starting in about 40% of extranodal lymphoid tissues, including the pharyngeal ring and intraperitoneal Wei, and showed swollen tonsils, pharyngeal mass, abdominal mass, abdominal pain. Some patients with nodular sclerosis HL can also be mainly for the mediastinal mass. HL can also be a small number of causes of fever of unknown treatment.
(2) HL usually first manifested as a superficial lymph nodes, and in quite a long time to remain stable or varying, after a certain way by the gradual expansion of the nearby lymph nodes group (but can be left unlocked over the mediastinal lymph nodes directly to the intra-abdominal spread, some people think, Department of retrograde extension along the thoracic duct). The NHL is the lack of regularity of the development of disease, many patients start to show in general for the whole body lymph nodes.
(3) HL-induced lymphadenopathy is often softer, more activities, and the base of the skin and lymph nodes children are often not mutually adhesion between tumor and NHL in particular, are often highly malignant lymph node infiltration of surrounding soft tissue or skin, form Hard to compare a fixed mass, such as the invasion and the surface of the skin flushing, edema, pain, late to ulceration.
(4) HL were more common fever, night sweats, skin War, Pi Yang, increased eosinophils, etc.; skin delayed hypersensitivity reaction to multiple antigens than common.
Symptoms of malignant lymphoma (5) In general, HL may develop slower, longer duration. Good response to treatment. The NHL (low grade types, in addition) is often rapid development, short course treatment of different responses, and even if mitigation is also easy to relapse and poor prognosis.

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