Prognostic factors of which

By | October 31, 2011

Based on years of clinical observation, the main prognostic factors of lung cancer include the following:
1. Lung cancer histological types of lung cancer histological types of lung cancer is an important prognostic factor in squamous cell carcinoma of the 5-year survival rate was 15.3%, 11.6% for adenocarcinoma, small cell undifferentiated carcinoma of the 5-year survival rate was 7.7%. With the recent development of bio-tech, even if the prognosis of lung cancer is also the same type and differentiation degree.
Prognostic factors of lung cancer 2. DNA times the size of lung carcinoma were detected by flow cytometry of DNA content showed that, DNA content was significantly prognostic factors for survival, studies show that same period, the same level and organization of the same type of lung cancer, there is often a different number of aneuploid cell subsets, DNA diploid 5-year survival rate was significantly higher than the aneuploidy.
3. P53 gene p53 mutation found in 80% of non-small cell lung cancer, there is abnormal expression of p53 gene were significantly higher than survival rates per p53 abnormal expression was short. Joint analysis of the expression of p53 mutations and rasp21, both negative patients had a longer survival, p53 mutation and expression of a more accurate rasp21 non-small cell lung cancer to determine the prognosis and recurrence risk.
4. 43-9F antigen 43-9F antigen immunohistochemical study ,43-9F antigen positive patients with squamous cell carcinoma antigen negative prognosis is better than the patients, but adenocarcinoma of the 43-9F antigen expression and survival time of dollars off. 43-9F extension L of the original expression on the prognosis of patients with squamous cell carcinoma than to determine N stage, and can reflect the primary tumor recurrence.
Prognostic factors of lung cancer 5. Tumor doubling time of 200 cases of primary lung cancer by statistical analysis, the tumor doubling time had a significant effect on prognosis, tumor doubling time is shorter, the worse the prognosis of primary lung cancer; tumor doubling time longer, the prognosis is more good.
6. Disease is on the later stage of disease, the lower survival rate, I include lung cancer, including surgery and non-surgical, the 5-year survival rate of up to 39.3%, E, E period were 11.7% and 4%, III of No one case of lung cancer survive for 3 years.
7. Lesions violations, the prognosis of metastatic sites of disease invasion and lymph node metastatic sites have an impact on lung cancer patients. Studies show that lung cancer in the same period, such as lung cancer if I pulmonary blood vessels, lymphatic tumor thrombus within it easy to recurrence and metastasis, so the prognosis is poor. III mediastinal lymph node metastasis of lung cancer was significantly worse prognosis. The pleura, chest wall violations were classified as pan significantly better prognosis of lung cancer, the two 5-year survival rates were 16.7% and 43.2%. Lymph node metastasis of lung cancer in each group next to the esophagus, lung under the ligament, subcarinal lymph node is the worst.
8. Apoptosis apoptotic index and mitotic index depends on the tumor histological type, high apoptotic index significantly better 5-year survival and disease-free survival. Squamous cell carcinoma with high mitotic mitosis than the low 5-year prognosis was good, and in adenocarcinoma, large cell carcinoma of the opposite. Before treatment, the apoptosis index and the level of mitotic cancer patients can predict treatment outcome to determine adenocarcinoma, large cell cancer predict recurrence and metastasis.
9. Treatment regimen in the correctness of any of the other lung cancer and prognosis are closely related. If I by the cox of the multivariate analysis of all factors that can influence the prognosis of treatment is the only factor. I treatment of lung cancer 5-year survival for non-surgical treatment of 3 times, respectively, 50% and between 12.3% -13.6%, while the comprehensive surgical treatment, mainly surgery and chemotherapy, the 5-year survival rate is greater than a single surgical treatment was 64%, in any stage, the type of the efficacy of combined treatment of lung cancer are the best.
Prognostic factors of lung cancer 10. Social and psychological factors determine prognostic factors, psychosocial factors are factors that can not be ignored. Mentally ill patients with early stage for a long period of anger and grief, the patient often can not afford a reality. At first most of the performance of temperament and rude, rude and unreasonable. Despair particularly severe, most patients appear weary of the idea, was disappointed in the future, especially in the production of a range of symptoms. After receiving treatment in reality, not only the patient takes more courage, more for patients in need of social and family fully understood, most of them because of side effects of treatment on the appearance of change, even worse because of illnesses brought them a lot of inconvenience. This requires that families and society to give them some encouragement and support to give them more care and help encourage patients to establish the confidence to overcome the disease. So that they can in a good atmosphere to live. However, due to a variety of social causes, such as medical costs rise, forcing the work environment, lack of awareness of disease, etc., many patients can not be timely medical treatment after the illness, the result lost the early diagnosis and treatment of the best period.

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