Esophageal side effects of chemotherapy drugs fluorouracil

By | March 20, 2012

Fluorouracil adverse reactions (1) gastrointestinal reactions. Is often delayed, and the medication after 5 – 7 days began to appear, the lower lip edge of a small water mark for the early symptoms of toxicity, and then produce oral leukoplakia, and gradually developed into erythema, ulcer, accompanied by loss of appetite appetite, nausea, vomiting; gastrointestinal mucosa may also have similar changes, there stool frequency increased, watery diarrhea, abdominal pain, severe blood loose stools, a few can be life threatening.
Fluorouracil adverse events (2) bone marrow suppression. Performance of white blood cells and thrombocytopenia, usually 10-14 days to a minimum value can be restored 2-3 weeks after treatment. Little effect on red blood cells.
Fluorouracil adverse reactions (3) nervous system toxicity. Fluorouracil can cause cerebellar symptoms in ataxia, dysarthria, weakness, usually appear later, is a long-term toxicity may be related to 5-FU metabolites fluoride salts on rubber arrested. 5-FU may cause serious central nervous system toxicity occur, but the incidence is not high, the central nervous system dysfunction was reversible. Severe central nervous system toxicity associated with fluorouracil dose, the body related to differences.
Fluorouracil adverse reactions (4) liver damage. Because in the liver metabolism, liver function it may have reversible damage.
Fluorouracil adverse reactions (5) other. In the course of fluorouracil, a few cases may have chest pain, rapid heart rate, ECG changes. On-segment elevation, T wave elevated or inverted, etc. At the same time, blood lactate dehydrogenase increased. These patients often have no history of heart disease nor hypertension, nor did previous chest radiotherapy.
Fluorouracil is directly toxic to the heart worthy of further exploration. Fluorouracil can also cause hair loss, dermatitis, skin and nail pigmentation.

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