Oxaliplatin side effects (1) neurotoxicity. Occurrence of acute neurological toxicity was 85% – 95%, mainly for sensory nerve abnormalities, such as distal or perioral paresthesia. l% – 12% of patients have characteristic appear insensitive pharynx and (or) paresthesia, increased cold case, the rate was 82%, 12% dysfunction after discontinuation symptoms, occasionally reversible acute throat sensation, or even have difficulty breathing or swallowing, feeling.
These acute symptoms rapidly, but relatively mild, brief, to restore the chronic neurotoxicity in the clinical and electrophysiological manifestations of uranium in both the cis neurotoxicity is very similar to the duration of these symptoms with drugs by the cumulative dose large and prolonged severity of the increase. The use of oxalic acid has been reported after surgical treatment of lead may increase the toxicity of these chronic nerve.
Oxaliplatin adverse events (2) gastrointestinal toxicity. Nausea and vomiting was 64.9%, of which 3 degrees or 4 degrees is 10.7%; diarrhea was 30_4%, of which 3 degrees or 4 degrees to 4.0%; mucositis was 6%.
Oxaliplatin side effects (3) hematologic toxicity. Blood with less toxicity, the occurrence rate is not high, mostly mild to moderate, severe rare. When combined with fluorouracil slightly Anhui, the neutral neutropenia and thrombocytopenia increased hematologic toxicity.
Oxaliplatin side effects (4) other. Mild transaminase elevation, rare fever, constipation, skin toxicity, discomfort after the injection, local phlebitis, no renal toxicity and alopecia.