Esophageal cancer chemotherapy drug methotrexate adverse Ridge

By | March 19, 2012

Methotrexate side effects Ridge (1) MTX dose-limiting toxicity was myelosuppression. High dose or long-term oral small dose can lead to significant bone marrow suppression, white blood cells and thrombocytopenia occurred in 4-14 days after treatment, 21 days recovery.
(2), gastrointestinal reactions. Gastritis, diarrhea, and the more common oral ulcer, nausea, vomiting and other gastrointestinal reactions are relatively light.
Methotrexate adverse Ridge (3) liver. Some people after a drug had abnormal liver function, long-term low-dose oral prone to cause liver cell necrosis, fatty liver, chronic liver fibrosis and even cirrhosis.
(4) the respiratory system. Long-term medication can cause coughing, shortness of breath, pneumonia, pulmonary fibrosis may be symptomatic and supportive treatment.
Methotrexate adverse Ridge (5) off the administration, some patients had chemical arachnoiditis.
(6) Some patients had dermatitis, skin Yan, skin pigmentation.
(7) central nervous system. There may be headache, slow, visual disturbances, aphasia, convulsions.
Methotrexate adverse Ridge (8) Urinary System. Large doses, there may be hematuria, proteinuria, oliguria, azotemia or uremia.

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