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Advocate uses genetic history to increase knowledge of hereditary cancer risk

The 33-year-old mother who has tested positive for the BRCA2 cancer gene is one of 12 people in her family over three generations linked to the gene or diagnosed with cancer. Now Koszegi is using her family’s genetic history to contribute to cancer research, prevention and treatment — with the aim of improving the quality of life for those facing hereditary risk…

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Dual therapy’s 1-2 punch knocks out drug-resistant lung cancer

In experiments that combined the drug the patient had taken with a second compound that blocks off this newly discovered resistance pathway, the researchers were able to durably wipe out cancer cells in mice implanted with cells from the drug-resistant tumor. “Even in cancers that are responding to targeted therapy by conventional criteria, resistance is […]

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Body’s cancer defenses hijacked to make pancreatic, lung cancers more aggressive

The team, from the Cancer Research UK Centre at the UCL (University College London) Cancer Institute, found that mutations in the KRAS gene interferes with protective self-destruct switches, known as TRAIL receptors, which usually help to kill potentially cancerous cells. The research, carried out in cancer cells and mice, shows that in cancers with faulty […]

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Personalized melanoma vaccines marshal powerful immune response

The tailor-made vaccines, given to three patients with advanced melanoma, appeared to increase the number and diversity of cancer-fighting T cells responding to the tumors. The finding is a boost to cancer immunotherapy, a treatment strategy that unleashes the immune system to seek out and destroy cancer. The research is reported April 2 in Science […]

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Strong grasp of immune response dynamics will enhance checkpoint blockade

“Identifying in advance who will benefit from treatment and developing combination therapies to improve and expand on current results will require us to decipher the dynamics of human immune response to tumors and their surrounding microenvironment,” said co-author Padmanee Sharma, M.D., Ph.D., professor of Genitourinary Medical Oncology and Immunology at The University of Texas MD […]

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Small RNA plays big role suppressing cancer

Researchers at UC Davis have unraveled some of these relationships, identifying several interactions that directly impact liver and colon cancer. The work provides new insights into how miR-22 operates and could potentially lead to new cancer therapies. The study was published in the Journal of Biological Chemistry. “There are quite a few molecules present in […]

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Herpesvirus activates RIG-I receptor to evade body’s immune system

Led by Pinghui Feng, Ph.D., associate professor of molecular microbiology and immunology at the Keck School of Medicine of USC, the team found that herpesvirus proteins activate retinoic acid-induced gene I (RIG-I) by removal of an amino group from the glutamine and asparagine amino acids through a process called deamidation. RIG-I is a cellular receptor […]

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Cancer genes turned off in deadly brain cancer

While standard chemotherapy drugs damage DNA to stop cancer cells from reproducing, the new method stops the source that creates those cancer cells: genes that are overexpressing certain proteins. “Our study identified miR-182 as a glioblastoma tumor suppressor that reduces the expression of several oncogenes that promote cancer development,” said senior author of the study […]

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Possible progress against Parkinson’s and good news for stem cell therapies

Parkinson’s, which affect as many 10 million people in the world, is caused by a depletion of dopamine-producing neurons in the brain. Current treatments include medications and electrical implants in the brain which causes severe adverse effects over time and fail to prevent disease progression. Several studies have indicated that the transplantation of embryonic stem […]

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Cancer Health Center | Women & Men Health and Cancer Treatments - Part 2