Tag Archives: society

Clinical practice guidelines address multimodality treatment for esophageal cancer

The guidelines, published in the November 2014 issue of The Annals of Thoracic Surgery, include nine evidence-based recommendations that address issues related to multimodality care, including neoadjuvant therapy (chemotherapy and radiation therapy given prior to surgery). The goal of this therapy is to reduce the extent of cancer before an operation to maximize the chance of obtaining a cure. “Despite the widespread enthusiasm for multimodality therapy and the myriad of its aspects, currently available data for each component of care are not truly definitive,” said Guideline Task Force Chair, Alex G. Little, MD, from the University of Arizona in Tucson. …

Improving breast cancer chemo by testing patient’s tumors in a dish — ScienceDaily

A team of biomedical engineers at Vanderbilt University headed by Assistant Professor Melissa Skala has developed the technique, which uses fluorescence imaging to monitor the response of three-dimensional chunks of tumors removed from patients and exposed to different anti-cancer drugs. In an article published last month by the journal Cancer Research the engineers describe applying the technique to the three major forms of breast cancer. They report that the test can detect significant drops in the metabolic activity levels of all three types of tumors within 72 hours when exposed to an effective drug whereas tumors that were resistant to a drug show no change…

Mushroom extract, AHCC, helpful in treating HPV

The results were presented at the 11th International Conference of the Society for Integrative Oncology in Houston today by principal investigator Judith A. Smith, Pharm.D., associate professor in the Department of Obstetrics, Gynecology and Reproductive Sciences at the UTHealth Medical School. Ten HPV-positive women were treated orally with the extract, AHCC (active hexose correlated compound) once daily for up to six months…

Chest radiation to treat childhood cancer increases patients’ risk of breast cancer

Wilms tumor is a rare childhood kidney cancer that can spread to the lungs. When this spread occurs, patients receive a relatively low dose of 12-14 Gray of radiation therapy to the entire chest. To see if such exposure to radiation affects patients’ risk of developing breast cancer, Norman Breslow, PhD, of the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle, led a team that studied nearly 2500 young women who had been treated for Wilms tumor during childhood and who had survived until at least 15 years of age. …

3-D printed facial prosthesis offers new hope for eye cancer patients following surgery

In the United States, more than 2,700 new cases of eye cancer are diagnosed each year, according to the American Cancer Society, and the mortality rate is high for the disease. Some patients undergo a life-saving surgery known as exenteration that involves removing the contents of the eye socket and other tissue…

Patients treated with radiation therapy who have tumors in left breast have comparable overall survival to those with tumors in right breast –…

Studies have shown that breast cancer patients treated with radiation therapy have improved local-regional recurrence, and breast cancer-specific survival after breast-conserving surgery and overall survival (OS) after mastectomy. Long-term follow-up of historic radiation therapy trials for breast cancer has demonstrated a potential increase in cardiac mortality. However, these studies used earlier modes of radiation therapy including Cobalt and orthovoltage radiotherapy, and did not employ CT-based planning, which allows for greater cardiac avoidance. Three recent studies suggest that cardiac mortality has not been greater for patients treated for left-sided breast cancer since the 1980s, when techniques allowing for greater cardiac avoidance became more commonplace[1-3]. …

Image Guided Radiation Therapy Is Commonly Used to Ensure Accuracy in Treating Pediatric Tumors

IGRT is the process of using frequent imaging, typically performed in the treatment room prior to radiation delivery, throughout a patient’s course of radiation therapy treatment to improve localization of the target and normal structures, which allows for more precise and accurate radiation delivery. IGRT is a common practice in both photon (traditional radiation therapy) and proton therapy to treat tumors close to sensitive structures and organs or in areas of the body prone to movement or change in shape. This study, “Practice patterns of photon and proton pediatric image guided radiation treatment: Results from an International Pediatric Research Consortium,” evaluates the use of IGRT in treatment planning for pediatric cancers in an international consortium comprised of seven institutions using either photon or proton therapy with dedicated pediatric expertise. Choosing optimal IGRT regimens that spare healthy tissue and organs is a particular concern for pediatric patients to help prevent potential late effects associated with the distribution of the radiation dose and the total radiation dose the patient receives. …

Personalized cellular therapy achieves complete remission in 90 percent of acute lymphoblastic leukemia patients studied

The new data, which builds on preliminary findings presented at the American Society of Hematology’s annual meeting in December 2013, include results from the first 25 children and young adults (ages 5 to 22) treated at the Children’s Hospital of Philadelphia and first five adults (ages 26 to 60) treated at the Hospital of the University of Pennsylvania. Twenty-seven of the 30 patients in the studies achieved a complete remission after receiving an infusion of these engineered “hunter” cells, and 78 percent of the patients were alive six months after treatment. “The patients who participated in these trials had relapsed as many as four times, including 60 percent whose cancers came back even after stem cell transplants. Their cancers were so aggressive they had no treatment options left,” said the study’s senior author, Stephan Grupp, MD, PhD, a professor of Pediatrics in Penn’s Perelman School of Medicine and director of Translational Research in the Center for Childhood Cancer Research at the Children’s Hospital of Philadelphia…