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Adult cells transformed into early-stage nerve cells, bypassing the pluripotent stem cell stage

Bypassing the ultra-flexible iPSC stage was a key advantage, says senior author Su-Chun Zhang, a professor of neuroscience and neurology. "IPSC cells can generate any cell type, which could be a problem for cell-based therapy to repair damage due to disease or injury in the nervous system." In particular, the absence of iPSC cells rules out the formation of tumors by pluripotent cells in the recipient, a major concern involving stem cell therapy. A second advance comes from the virus that delivers genes to reprogram the adult skin cells into a different and more flexible form…