Researchers target the cell’s ‘biological clock’ in promising new therapy to kill cancer cells
Dr. Jerry W. Shay, Professor and Vice Chairman of Cell Biology at UT Southwestern, and colleague, Dr. …
Tag Archives: sciencedaily
Cancer treatment potential discovered in gene repair mechanism
If the laboratory findings are supported by tests in animal models, the breakthrough could hold the promise of increasing the effectiveness of radiation and chemotherapy in shrinking or even eliminating tumors. The key is to build up a “good” protein — p53-binding protein 1 (53BP1) — so that it weakens the cancer cells, leaving them more susceptible to existing cancer-fighting measures. The breakthrough detailed appeared in the Nov. 24 online edition of the journal PNAS (Proceedings of the National Academy of Sciences). …
Cancer-causing mutation discovered in 1982 finally target of clinical trials
“We didn’t initially discover the gene. But now technology lets us find the gene in actual patient samples and drugs are available to target these gene rearrangements, making it possible to treat TRK cancers in clinical trials in ways we only dreamed of thirty-two years ago,” says Robert C. …
Rare cancer’s genetic pathway identified by scientists
SFU molecular biology and biochemistry professor Jack (Nansheng) Chen and three of his lab members collaborated with Chinese researchers to identify how these mutations affect genes and signalling pathways that might drive the formation of tumours in ICC. …
Risk for leukemia after treatment for early-stage breast cancer higher than reported — ScienceDaily
The study team reviewed data on 20,063 breast cancer patients treated at eight U.S. cancer centers between 1998 and 2007 whose cancer recurrence and secondary cancer rates were recorded in a database kept by the National Comprehensive Cancer Network. …
Egg and sperm race: Scientists create precursors to human egg and sperm
When an egg cell is fertilised by a sperm, it begins to divide into a cluster of cells known as a blastocyst, the early stage of the embryo. Within this ball of cells, some cells form the inner cell mass – which will develop into the foetus – and some form the outer wall, which becomes the placenta…
Scientists zero in on how lung cancer spreads
The researchers at the Cancer Research UK Manchester Institute discovered that the ties which lash cells together — controlled by a protein called TIAM1 — are chopped up when cell maintenance work goes wrong. …
This Endoscope Zaps Tumors
It may soon serve another purpose: zapping tumors. The biomedical advancement, which is under development at the University at Buffalo, could make chemotherapy more efficient, reduce its side effects and improve how doctors treat some of the most deadly forms of cancer. “We are developing a novel endoscopic device that will improve our ability to detect and destroy cancer cells,” says Ulas Sunar, PhD, a research assistant professor in UB’s Department of Biomedical Engineering and the principal investigator of a National Institutes of Health grant that supports the research. Conventional endoscopic imaging has limitations. …
Researchers map paths to cancer drug resistance — ScienceDaily
By mapping the specific steps that cells of melanoma, breast cancer and a blood cancer called myelofibrosis use to become resistant to drugs, the researchers now have much better targets for blocking those pathways and keeping current therapies effective. The findings are published in two papers Dec…
Test predicts response to treatment for complication of leukemia stem cell treatment
Patients with fatal blood cancers like leukemia often require allogenic stem cell SCT to survive. Donor stem cells are transplanted to a recipient, but not without the risk of developing GVHD, a life-threatening complication and major cause of death after SCT. The disease, which can be mild to severe, occurs when the transplanted donor cells (known as the graft) attack the patient (referred to as the host). …