Tag Archives: official

Interstitial lung disease is significant risk factor for lung inflammation

ILD is a group of diseases that cause scarring and stiffing of the tissue and space around the air sacs in the lungs, which results in diminished gas exchange. The incidence of ILD among lung cancer patients is higher than in the general population as tobacco smoking is a common risk factor for both. Some lung cancer patients with ILD may not be considered good candidates for surgical therapy. …

Support for fecal testing in familial colorectal cancer screening

“In our study, repeat FIT screening detected all colorectal cancers in asymptomatic first-degree relatives of patients with colorectal cancer,” said lead study authors Enrique Quintero, MD, PhD, and Marta Carrillo, MD, from Hospital Universitario de Canarias, Tenerife, Spain. “These findings suggest that FIT screening should potentially be considered for familial screening, especially in populations where colonoscopy capacity is limited and/or compliance with colonoscopy is a concern.” Researchers conducted a prospective randomized trial to compare the efficacy of repeated FITs and colonoscopy in detecting advanced tumors in family members of patients with colorectal cancer. The study included 1,918 first-degree relatives of patients with colorectal cancer, who were randomly split into two groups to receive either a single colonoscopy examination or three FITs — one a year for three years…

Anaplastic lymphoma kinase immunohistochemistry testing comparable to, if not better than, fluorescence in situ hybridization testing

ALK tyrosine kinase inhibitors (TKIs) shrink tumors and increase progression-free survival in late-stage non-small cell lung cancer (NSCLC) patients positive for ALK as determined by the fluorescence in situ hybridization (FISH) test, a test for DNA rearrangement within the gene. …

Decision Analysis Can Help Women Make Choices about Breast Reconstruction — ScienceDaily

The special topic article by Mia K. Markey, PhD, and colleagues of The University of Texas at Austin and The University of Texas MD Anderson Cancer Center, Houston, introduces plastic surgeons to the use of decision analysis to help women navigate decisions about breast reconstruction after mastectomy for breast cancer. “Decision analysis provides structure for methodic, thoughtful decision-making through the use of reason, logic, and mathematics,” the authors write. Decision Analysis Helps Sort Through Breast Reconstruction Options Decision analysis is defined as ” an exhaustive, iterative process that involves identifying alternatives, obtaining information about the uncertainty of outcomes, and clarifying preferences and values.” Routinely used in business, decision analysis is increasingly applied to complex medical decisions as well. …

Gene that increases incidence of acute myelogenous leukaemia discovered

Led by Associate Professor Chng Wee Joo, Deputy Director and Senior Principal Investigator at CSI Singapore and Director of the National University Cancer Institute, Singapore, the scientists discovered that inhibition of Leo1 and Leo1 downstream signalling pathways provide an avenue for targeted treatment of AML. The findings were recently published in Cancer Research, the official journal of the American Association of Cancer Research. …

Men who exercise less more likely to wake up to urinate — ScienceDaily

The study by Kate Wolin, ScD, and colleagues is published online ahead of print in Medicine & Science in Sports & Exercise, the official journal of the American College of Sports Medicine. Nocturia is the most common and bothersome lower urinary tract symptom in men. It can be due to an enlarged prostate known as benign prostatic hyperplasia (BPH) — as the prostate enlarges, it can squeeze down on the urethra…

High concordance between EGFR mutations from circulating-free tumor DNA and tumor tissue in non-small cell lung cancer

EGFR tyrosine kinase inhibitor (TKI) therapy is approved for EGFR activating mutation positive patients with advanced NSCLC, but the standard for determining mutation status is with DNA derived directly from tumor tissue, which can be limited or not available. …

Deletion predicts survival in advanced non-small cell lung cancer

The BIM protein can activate the programmed cell death also known as the apoptotic pathway in cells. BIM deletion has been detected in 12.8% of the Asian population but is very rarely observed in the Caucasian population. All NSCLC patients treated with any therapy, targeted or chemotherapeutic, ultimately fail their therapy but at varying times. …