Tag Archives: network

High-dose radiation therapy for bladder cancer has comparable tumor control compared to surgery

Cystectomy (partial or whole bladder removal surgery) is often the standard treatment for patients with muscle-invasive bladder cancer; however, advanced RT techniques that spare the bladder may be an effective alternative for patients who are unsuitable for or unwilling to undergo cystectomy. This research was conducted to determine if some of the drawbacks of RT of the bladder, such as local recurrence and late toxicity risks, could be reduced with a lower dose of RT being delivered to the areas of the bladder outside of the tumor region, and to assess the tumor control and toxicity of RT. …

Step closer to custom-building new blood vessels

The results appear online this week in the Proceedings of the National Academy of Sciences. "In demonstrating the ability to rebuild a microvascular bed in a clinically relevant manner, we have made an important step toward the construction of blood vessels for therapeutic use," says Sharon Gerecht, Ph.D., an associate professor in the Johns Hopkins University Department of Chemical and Biomolecular Engineering, Physical Sciences-Oncology Center and Institute for NanoBioTechnology. "Our findings could yield more effective treatments for patients afflicted with burns, diabetic complications and other conditions in which vasculature function is compromised." Gerecht’s research group and others had previously grown blood vessels in the laboratory using stem cells, but barriers remain to efficiently producing the vessels and using them to treat patients. For the current study, the group focused on streamlining the new growth process. …

Facebook helped boost organ donor registration

Raising awareness of organ donation on social media websites can help boost donation rates, according to a new study. Facebook began allowing users to make their status as organ donors visible in their profiles in May 2012, and on the first day of the change, about 13,000 people in the U.S. registered to become organ donors 20 times more than the average number of daily registrations. The effect of the social media initiative on its first day varied across states, ranging from a seven-fold increase in registrations in Michigan, to 100-fold increase in Georgia, the results showed. The findings mean that social media might be an effective tool for encouraging organ donation, as well as tackling other public health problems in which communication and education are essential, the researchers said. Our research speaks to on-going efforts to address the organ availability crisis in the United States. It also suggests that social media and social networks may be valuable tools in re-approaching refractory public health problems, said study researcher Dr. Andrew Cameron, the surgical director of liver transplantation at Johns Hopkins Hospital in Baltimore. Today, more than 118,500 people in the U.S. are on the waiting list for organs, and one name is added to the list every ten minutes, according to the United Network for Organ Sharing. On average, 18 people die every day waiting for an organ. Despite countless previous efforts, organ donation rates in the United States have not grown, while need for transplants has risen dramatically. Therefore, new efforts are needed to boost organ donation through public education, the researchers said. The Facebook initiative t let users add their organ-donation status to the timeline for their friends and family to see. It also directed people to the official organ donation registry websites of their states. The results showed high registration rates following the Facebook initiative, compared with usual rates at the Department of Motor Vehicles (DMV). The boost may stem from the fact that people are more open to making decisions about sensitive and difficult topics when they are in an environment “amongst friends,” compared with the environment at the DMV, the researchers said. However, after the initial spike, registration rates diminished over the following weeks. The researchers said this shows more work is needed to find ways to sustain the increase. “The next challenge for efforts like the organ donor initiative will be utilization of social media applications like Facebook, Twitter, YouTube or Instagram more effectively and more durably,” the researchers wrote in the study, which was published today (June 18) in the American Journal of Transplantation. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/06/18/facebook-helped-boost-organ-donor-registration/

Gene variants may predict who will benefit from breast cancer prevention drugs

The work represents a major step toward truly individualized breast cancer prevention in women at high risk for the disease based on their age, family history of breast cancer, and personal medical history. "Our study reveals the first known genetic factors that can help predict which high-risk women should be offered breast cancer prevention treatment and which women should be spared any unnecessary expense and risk from taking these medications," said the study’s lead scientist, James N. Ingle, M.D., professor of oncology at the Mayo Clinic in Rochester, Minn. "We also discovered new information about how the drugs tamoxifen and raloxifene work to prevent breast cancer." Ingle and Mayo-based colleagues in the NIH Pharmacogenomics Research Network (PGRN) conducted the study in collaboration with PGRN-affiliated researchers at the RIKEN Center for Genomic Medicine in Tokyo. …

First prospective trial shows molecular profiling timely for tailoring therapy

CUSTOM is the first completed prospective clinical trial that used genetic analysis alone to assign cancer treatment for patients with one of three different cancers. "We expected it would take five years to enroll 600 patients into CUSTOM. But in less than two years, 668 patients were recruited," says the study’s lead investigator, Giuseppe Giaccone, MD, PhD, associate director for clinical research at Georgetown Lombardi Comprehensive Cancer Center. "This was a surprise to all of us, especially since patients with advanced cancer who already had biopsies needed to undergo an additional biopsy for the study. …

Breakthrough in the understanding of how pancreatic cancer cells ingest nutrients points to new drug target

Now new research reveals a possible chink in the armor of this recalcitrant disease. Many cancers, including pancreatic, lung, and colon cancer, feature a mutated protein known as Ras that plays a central role in a complex molecular chain of events that drives cancer cell growth and proliferation…