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Treatment breakthrough for advanced bladder cancer

Published today in Nature, the study examined an antibody (MPDL3280A) which blocks a protein (PD-L1) thought to help cancer cells evade immune detection. In a phase one, multi-centre international clinical trial, 68 patients with advanced bladder cancer (who had failed all other standard treatments such as chemotherapy) received MPDL3280A, a cancer immunotherapy medicine being developed by Roche. In addition, patients were all tested for the protein PD-L1 and around 30 were identified as having PD-L1 positive tumours. After six weeks of treatment, 43 per cent of PD-L1-positive patients found their tumour had shrunk…

Potential predictive biomarker for response to PD-L1 checkpoint blocker found

The antibody drug, known as MPDL3280A, inhibits the brake protein, PD-L1, reviving the response by immune killer T cells, which target and destroy the cancer cells. In recent clinical trials, the PD-L1 checkpoint blocker caused impressive shrinkage of kidney, melanoma, and lung tumors. But, as with other immunotherapy drugs, many patients saw no benefit. …

Trial shows new imaging system may cut X-ray exposure for liver cancer patients

In a report prepared for presentation Dec. 3 at the 100th annual meeting of the Radiological Society of North America in Chicago (abstract #SSM24-02), the researchers described the results of a clinical trial of the imaging system AlluraClarity, made by Philips Healthcare, on 50 patients with liver cancer. …

Experimental Ebola vaccine appears safe, prompts immune response

“The unprecedented scale of the current Ebola outbreak in West Africa has intensified efforts to develop safe and effective vaccines, which may play a role in bringing this epidemic to an end and undoubtedly will be critically important in preventing future large outbreaks,” said NIAID Director Anthony S. Fauci, M.D. …

8 things you only ask Google

Click over to the history tab in your browser and scan what's there. We're going to bet there's at least one semi-embarrassing health question you've been trying to get to the bottom of, but would never breathe a word about to your doctor.  To help you save time (and face), we canvassed doctors across America about common embarrassing symptoms and guess what? None of them flinched. They also had some fascinating clues as to what might be causing them—and what you can do about it. Here, strange symptoms you'd rather not talk about—explained. Why do I pee when I run? “Exercise-induced incontinence is not uncommon in women, and it's usually caused by one of two factors: “1. Stress incontinence occurs when the pressure inside the abdomen exceeds the resistance at the neck of the bladder (for example: if the urethral sphincter muscle doesn't close with enough force). Running or other strenuous physical exercise could cause this increase in abdominal pressure and subsequent urinary leakage. (Sound familiar…

10 things you only ask Google

Click over to the history tab in your browser and scan what's there. We're going to bet there's at least one semi-embarrassing health question you've been trying to get to the bottom of, but would never breathe a word about to your doctor.  To help you save time (and face), we canvassed doctors across America about common embarrassing symptoms and guess what? None of them flinched. They also had some fascinating clues as to what might be causing them—and what you can do about it. Here, strange symptoms you'd rather not talk about—explained. Why do I pee when I run? “Exercise-induced incontinence is not uncommon in women, and it's usually caused by one of two factors: “1. Stress incontinence occurs when the pressure inside the abdomen exceeds the resistance at the neck of the bladder (for example: if the urethral sphincter muscle doesn't close with enough force). Running or other strenuous physical exercise could cause this increase in abdominal pressure and subsequent urinary leakage. (Sound familiar? See 11 Fixes For A Weak Bladder.) “2. The other main reason is bladder overactivity, where the muscles of the wall of the bladder squeeze when they should be relaxed (during bladder filling). This gives people a sense of urgency, and may cause them to leak urine. “If you're experiencing urine leakage with running or other physical exercise, I encourage you to seek help from a urologist or your primary health care provider.” —Dr. Tomas L. Griebling, professor and vice-chair of urology at the University of Kansas My thighs chafe when I walk. What's up? …