Keeping centrioles in check to ensure proper cell division

By | July 25, 2013

Their results are published in the journal Current Biology today.

Centrioles — orchestrators of cell division

When our cells divide, their genetic material — in the form of X-shaped chromosomes — is aligned in the middle of the cell and segregated to opposite poles of the cell by a spindle of long tubular fibers, so-called microtubules. The structures that organize the two poles of the spindle in animal cells are called centrosomes. Each centrosome consists of two cylindrically shaped centrioles that are positioned perpendicular to each other and surrounded by an amorphous dense mass called the pericentriolar material (PCM). At the end of cell division, the two centrioles inherited by each daughter cell separate, and later each of them forms a new centriole. This ensures that another bipolar spindle can be set up by two centrosomes when the cell divides again. Precise control of centriole separation and duplication is therefore essential for successful cell division. Abnormal centrosome numbers are commonly observed in human cancers and are thought to be at least in part responsible for the improper distribution of the genetic material that is a hallmark of many cancer cells.

The PCM — the glue that keeps centrioles together

Until now, it was unclear how centrioles are held together and how their separation at the end of cell division is so precisely regulated. Gabriela Cabral, a PhD student in the lab of Alex Dammermann at the Center for Molecular Biology of the University of Vienna, explains: "Many people thought that centrioles are held together by the same glue as chromosomes, a substance called cohesin, which is destroyed during cell division. We found this to be true only in the very specialized circumstances surrounding fertilization. In all other cases, as in the subsequent cell divisions following fertilization, the glue that holds centrioles together is actually the PCM." These findings explain previously conflicting data on the mechanism of centriole separation. Alex Dammermann adds: "The surprising finding that there are actually two cellular mechanisms for controlling centriole separation was only possible because we use the nematode worm C. elegans as our model organism. Would we have used cell cultures we would have never found that centriole separation works differently in different developmental contexts."

Stem cell fate and cancer

The dense mass of the PCM that entraps the sister centrioles is itself disassembled at the end of cell division. The microtubules that are responsible for separating the genetic material also appear to be involved in pulling the PCM and centrioles apart. This tightly regulated process is critical to ensure that both daughter cells will later have the correct centrosome numbers when they divide. This is important to avoid missegregation of the genetic material, which may result in cell death or tumor formation. Interestingly, centrosomes have also been linked to the segregation of cell fate determinants. Gabriela Cabral explains: "When a stem cell divides, it doesn’t produce two identical daughter cells as normal cells do. It produces another stem cell and a daughter cell that may differentiate into one of many specialized cell types." What these cell fate determinants are and how they are distributed when a stem cell divides is another big question. However, it is known that centrosomes are also involved in this process. Alex Dammermann says: "Our results show that the PCM still harbors many surprises. One of our current research goals is to examine how this largely mysterious accumulation of cellular material is organized and we hope that a better knowledge of this will help us understand how centrosomes perform their manifold functions in the cell."

source : http://www.sciencedaily.com/releases/2013/07/130723113707.htm

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