Cachexia and interleukin IL-1: interleukin IL-1 is the single core factor, mainly by activated mononuclear macrophages, many other kinds of cells can synthesize and secrete IL-l, such as dendritic cells, Langerhans cells, fibroblasts, epithelial cells, endothelial cells, brain glial cells, mesangial cells, NK cells, activated B cells.
Cachexia and interleukin IL-1: the performance of its concentration-dependent biological effects in vivo, in physiological concentrations (10.2 – 10.l4mml / L major role in local immune regulation since, at high concentrations, can the role of endocrine-shaped body , causing fever. IL-l itself is an endogenous pyrogen substances can induce the hepatic synthesis of acute phase proteins, causing metabolic consumption. hypothalamus of food, the central section of a IL-l and TNF- receptor, IL- l and TNF may be a direct effect of the hypothalamus produce anorexia.
IL-l induced changes in rat eating and tumor cachexia as early as the performance of similar types of food begins to reduce, then reduce the number. It was also present within the central nervous system, IL-l concentration was negatively correlated with the animals eat, so that the IL-l acts on the ventral hypothalamic nucleus caused by anorexia. It was also found in the ventral hypothalamus of rats injected with IL-l receptor antagonist, significantly improved animal phenomenon of anorexia.
Animal experiments showed that cachexia and interleukin IL-1, and the only effect of anorexia is closely related with the colored plastic. Stimulate the host immune system, tumor growth, resulting in it and some other cytokines, affect the body's metabolism, plasma tryptophan concentration and the blood-brain barrier one, the brain tryptophan levels increased, so that the release increases, and thus lead to anorexia. In addition to eating outside influence, IL-l can also cause changes in body composition, IL-l lead to liver protein synthesis, acute phase protein and ACTH release, inhibition of lipoprotein lipase activity.
Cachexia and interleukin IL-1: application of IL-l antibody, or IL-l receptor antagonist may slow tumor growth IJ Qi to improve the diet, save the fat, which further confirmed the occurrence of cancer cachexia in patients with the role. However, only a few studies found that tumor-bearing animals or cancer patients with increased production of IL-l, this phenomenon may be explained, and TNF-a, like, can be a self-or paracrine secretion of neurotransmitters and hormones are not kind of messenger.