Gene therapy of pancreatic cancer

By | April 16, 2012

Pancreatic cancer gene therapy, gene therapy research in recent years, cancer treatment is a hot spot and hope. Gene therapy include: tumor suppressor gene replacement therapy, gene directed prodrug activation therapy and antisense nucleotide import, immune toxin therapy and cytokines.
Replacement therapy using tumor gene mutations in oncogenes or tumor suppressor gene wild-type gene or alternative to inhibit cancer tumor suppressor gene deletion, so that tumor growth was inhibited and apoptosis of tumor cells, the main application in pancreatic tumor suppressor p16INK also compared gene p53, using retroviral or adenoviral vector containing wild type p16 or the p53 tumor suppressor gene mutations in cancer cells, in vivo and in vitro can inhibit the growth of cancer cells.
Gene directed prodrug activation therapy (gene-directed prodrug acti vation therapy, GPAT) is the principle guide people to the tumor cells, a mammalian expression itself is not very low expression or genes whose expression product (enzyme) on cell-free toxicity, but the species can fruit very low non-toxic or toxic prodrug into a toxic drug, killing target cells. Drug sensitivity gene transfected tumor cells, and then given to non-toxic prodrug into a toxic by drugs, which kill tumor cells, these genes also known as "suicide gene." Commonly used slightly Xiao thymus kinase HSV HSV / TK and the cellular source of bacteria and fungi Yu Wan deaminase CD.
Pancreatic cancer gene therapy, antisense nucleotide import treatment: antisense nucleotide (antisense olignucleotide) is a special sequence of DNA or RNA complementary oligo nucleotides, and the target gene can effectively block the stare transcription of the gene product, thereby inhibiting cancer cell growth.

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